Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study

被引：12

作者：

Cheng, Ching-Yao ^{[1
,2
]}

Chen, Cheng-Hsu ^{[3
,4
,5
]}

Wu, Ming-Fen ^{[1
]}

Wu, Ming-Ju ^{[3
,6
,7
,8
]}

Chen, Jun-Peng ^{[9
]}

Liu, Ying-Mei ^{[1
]}

Hou, Yu-Chi ^{[2
]}

Wang, Hue-Yu ^{[10
,11
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Pharm, Taichung 40705, Taiwan

[2] China Med Univ, Sch Pharm, Taichung 40402, Taiwan

[3] Taichung Vet Gen Hosp, Div Nephrol, Dept Internal Med, Taichung 40705, Taiwan

[4] Tunghai Univ, Dept Life Sci, Taichung 40704, Taiwan

[5] China Med Univ, Sch Med, Coll Med, Taichung 40402, Taiwan

[6] Chung Shan Med Univ, Sch Med, Taichung 40402, Taiwan

[7] China Med Univ, Grad Inst Clin Med Sci, Coll Med, Taichung 40402, Taiwan

[8] Natl Chung Hsing Univ, Grad Inst Biomed Sci, Taichung 40227, Taiwan

[9] Taichung Vet Gen Hosp, Biostat Task Force, Taichung 40705, Taiwan

[10] Chi Mei Med Ctr, Dept Pharm, Tainan 71004, Taiwan

[11] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan 71710, Taiwan

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2020年 / 17卷 / 12期

关键词：

immunosuppressant; post-transplant diabetes mellitus; risk factor; survival rate; NEW-ONSET HYPERGLYCEMIA; KIDNEY-TRANSPLANTATION; TACROLIMUS; IMMUNOSUPPRESSION; METAANALYSIS; GUIDELINES; MANAGEMENT; RECIPIENTS; SIROLIMUS; MORTALITY;

D O I：

10.3390/ijerph17124581

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Post-transplant diabetes mellitus (PTDM) is associated with infection, cardiovascular morbidity, and mortality. A retrospective cohort study involving patients who underwent renal transplantation in a transplantation center in Taiwan from January 2000 to December 2018 was conducted to investigate the incidence and risk factors of PTDM and long-term patient and graft survival rates. High age (45-65 vs. <45 years, adjusted odds ratio (aOR) = 2.90, 95% confidence interval (CI) = 1.64-5.13,p< 0.001), high body mass index (>27 vs. <24 kg/m(2), aOR = 5.35, 95% CI = 2.75-10.42,p< 0.001), and deceased organ donor (cadaveric vs. living, aOR = 2.01, 95% CI = 1.03-3.93,p= 0.04) were the three most important risk factors for the development of PTDM. The cumulative survival rate of patients and allografts was higher in patients without PTDM than in those with PTDM(p= 0.007 and 0.041, respectively). Concurrent use of calcineurin inhibitors and mammalian target of rapamycin inhibitors (mTORis) decreased the risk of PTDM (tacrolimus vs. tacrolimus with mTORi, aOR = 0.28, 95% CI = 0.14-0.55,p< 0.001). Investigating PTDM risk factors before and modifying immunosuppressant regimens after transplantation may effectively prevent PTDM development.

引用

页码：1 / 12

页数：11

共 33 条

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