Microneedles as an Alternative Strategy for Drug Delivery

被引:0
作者
Morales-Florido, M., I [1 ,2 ,4 ]
Miranda-Calderon, J. E. [2 ]
Gomez-Samano, M. A. [3 ]
Escobar-Chavez, J. J. [4 ]
机构
[1] Univ Autonoma Metropolitana, Doctorado Ciencias Biol & Salud, Mexico City, DF, Mexico
[2] Univ Autonoma Metropolitana, Lab Farm Mol & Liberac Controlada, Dept Sistemas Biol, Xochimilco, Mexico
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metabolismo, Ciudad De Mexico, Mexico
[4] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Unidad Invest Multidisciplinaria Lab 12 Sistemas, Mexico City, DF, Mexico
关键词
SOLID LIPID NANOPARTICLES; TRANSDERMAL DELIVERY; DISSOLVING MICRONEEDLES; INFLUENZA VACCINATION; PERCUTANEOUS DELIVERY; HOLLOW MICRONEEDLES; INTRADERMAL VACCINE; FABRICATION PROCESS; PROTEIN DELIVERY; IN-VITRO;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The transdermal route has been widely studied in the last decade due to its multiple advantages, where one of the most promising transdermal systems are microneedles, these allow the delivery of drugs in a painless way and with easy application, being very attractive for patients with chronic treatments. This review highlights the new research that develops this approach to transdermal therapies, including examples of materials and methods used for their manufacture and presenting an overview of the clinical trials currently available in Cochrane in a demonstrative way to understand the growing popularity of this strategy.
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收藏
页码:93 / 109
页数:17
相关论文
共 121 条
[1]   Microneedle-mediated vaccine delivery: Harnessing cutaneous immunobiology to improve efficacy [J].
Al-Zahrani, Sharifa ;
Zaric, Marija ;
McCrudden, Cian ;
Scott, Chris ;
Kissenpfennig, Adrien ;
Donnelly, Ryan F. .
EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (05) :541-550
[2]   Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].
Alexis, Frank ;
Pridgen, Eric ;
Molnar, Linda K. ;
Farokhzad, Omid C. .
MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515
[3]   Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum [J].
Alkilani, Ahlam Zaid ;
McCrudden, Maeliosa T. C. ;
Donnelly, Ryan F. .
PHARMACEUTICS, 2015, 7 (04) :438-470
[4]   Dissolvable microneedle fabrication using piezoelectric dispensing technology [J].
Allen, Evin A. ;
O'Mahony, Conor ;
Cronin, Michael ;
O'Mahony, Thomas ;
Moore, Anne C. ;
Crean, Abina M. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 500 (1-2) :1-10
[5]   A Novel Transdermal Protein Delivery Strategy via Electrohydrodynamic Coating of PLGA Microparticles onto Microneedles [J].
Angkawinitwong, Ukrit ;
Courtenay, Aaron J. ;
Rodgers, Aoife M. ;
Larraneta, Eneko ;
McCarthy, Helen O. ;
Brocchini, Steve ;
Donnelly, Ryan F. ;
Williams, Gareth R. .
ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (11) :12478-12488
[6]   Beat diabetes: an urgent call for global action [J].
不详 .
LANCET, 2016, 387 (10027) :1483-1483
[7]  
[Anonymous], 2018, [No title captured], P199
[8]  
[Anonymous], 2020, ClinicalTrials. gov ID NCT05513001
[9]  
Ansaldi F, 2012, EXPERT REV VACCINES, V11, P17, DOI [10.1586/erv.11.154, 10.1586/ERV.11.154]
[10]   Micro-scale devices for transdermal drug delivery [J].
Arora, Anubhav ;
Prausnitz, Mark R. ;
Mitragotri, Samir .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 364 (02) :227-236