Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection

被引：9

作者：

Barrettt, Colm ^{[1
]}

O'Sullivan, Finbarr ^{[2
]}

Barry, Sean ^{[1
]}

Grygoryev, Konstantin ^{[1
]}

O'Gorman, Donal ^{[2
]}

O'Mahony, Conor ^{[1
]}

O'Riordan, Alan ^{[1
]}

机构：

[1] Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland

[2] Dublin City Univ, Sch Hlth & Human Performance, Dublin, Ireland

来源：

2019 IEEE SENSORS | 2019年

基金：

爱尔兰科学基金会;

关键词：

Interstitial fluid; glucose sensing; pain-free polymer replication; microneedles; cytotoxicity analysis; DRUG; RISK;

D O I：

10.1109/sensors43011.2019.8956509

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Fabrication and characterization of polymer microneedle arrays, compatible with in-vivo glucose sensing, is described. The process generates a polymer microneedle electrode array comprised of an on-chip working, counter and reference electrodes. Glucose oxidase was entrapped in an o-phenylenediamine/sulphonated-beta-cyclodextrin polymer matrix at working electrodes The sensor array demonstrated glucose detection over the range of 0.5 - 19.5 mM.An interference study and a preliminary cytotoxicity study were carried to assess the sensors potential for future use in interstitial fluid.

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页数：4

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