miRNA-124 in Immune System and Immune Disorders

被引：87
作者：
Qin, Zhen [1 ]
Wang, Peng-Yuan [1 ]
Su, Ding-Feng [1 ]
Liu, Xia [1 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacol, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2016年 / 7卷
基金：
中国国家自然科学基金;
关键词：
miRNA-124; biomarker; target; immunity; immune disorders; FIBROBLAST-LIKE SYNOVIOCYTES; MICRORNA BIOMARKERS; ULCERATIVE-COLITIS; CROHNS-DISEASE; EXPRESSION; MACROPHAGES; ACTIVATION; INFECTION; DIFFERENTIATION; RECOGNITION;
D O I：
10.3389/fimmu.2016.00406
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years, miR-124 has emerged as a critical modulator of immunity and inflammation. Here, we summarize studies on the function and mechanism of miR-124 in the immune system and immunity-related diseases. They indicated that miR-124 exerts a crucial role in the development of immune system, regulation of immune responses, and inflammatory disorders. It is evident that miR-124 may serve as an informative diagnostic biomarker and therapeutic target in the future.
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页数：8
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