Selective serotonin reuptake inhibitors treatment effects on auditory measures in depressed female subjects

被引：15

作者：

Gopal, KV ^{[1
]}

Briley, KA ^{[1
]}

Goodale, ES ^{[1
]}

Hendea, OM ^{[1
]}

机构：

[1] Univ N Texas, Dept Speech & Hearing Sci, Denton, TX 76203 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 520卷 / 1-3期

关键词：

serotonin; selective serotonin reuptake inhibitor; auditory measure; transient evoked emission; auditory evoked potential; SCAN-A;

D O I：

10.1016/j.ejphar.2005.07.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of this study was to evaluate the auditory effects of selective serotonin reuptake inhibitors (SSRI), known to enhance serotonin (5-HT) transmission in the brain. The experimental group consisted of 14 clinically depressed female subjects, and the control group consisted of I I non-depressed females. A battery of tests was administered to the experimental group while on and off of SSRI medication. The control group was also administered the test battery twice. Results indicated no significant differences in the control group between sessions. The experimental group showed significantly smaller transient evoked emissions, higher SCAN-A (auditory processing test) composite scores, and smaller amplitude growth functions for Auditory brainstem response peak V and Auditory late response peak N1P2 while on SSRI medication. The increased 5-HT levels in the presence of SSRI (due to reduced reuptake of 5-HT) may be contributing to the significant changes seen in auditory measures with the experimental group. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：59 / 69

页数：11

共 48 条

[1]

[Anonymous], 1997, BIOPSYCHOLOGY

[2]

Azmitia E C, 1986, Adv Neurol, V43, P407

[3]

Beck A. T., 1996, Manual for the Beck Depression Inventory. Psychological corporation

[4]

BECK AS, 1999, J CLIN PSYCHOL, V55, P117

[5] BINAURAL NOISE SUPPRESSES LINEAR CLICK-EVOKED OTOACOUSTIC EMISSIONS MORE THAN IPSILATERAL OR CONTRALATERAL NOISE [J].

BERLIN, CI ;

HOOD, LJ ;

HURLEY, AE ;

WEN, H ;

KEMP, DT .

HEARING RESEARCH, 1995, 87 (1-2) :96-103

[6] Effects of fluoxetine and norfluoxetine on 5-hydroxytryptamine metabolism in blood platelets and brain after administration to rats [J].

Bourdeaux, R ;

Desor, D ;

Lehr, PR ;

Younos, C ;

Capolaghi, B .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1998, 50 (12) :1387-1392

[7] Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant [J].

Bruder, GE ;

Stewart, JW ;

Tenke, CE ;

McGrath, PJ ;

Leite, P ;

Bhattacharya, N ;

Quitkin, FM .

BIOLOGICAL PSYCHIATRY, 2001, 49 (05) :416-425

[8] DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE-IMMUNOREACTIVE, SEROTONIN-IMMUNOREACTIVE, DOPAMINE-BETA-HYDROXYLASE-IMMUNOREACTIVE, TYROSINE HYDROXYLASE-IMMUNOREACTIVE FIBERS IN MONKEY PRIMARY AUDITORY-CORTEX [J].

CAMPBELL, MJ ;

LEWIS, DA ;

FOOTE, SL ;

MORRISON, JH .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 261 (02) :209-220

[9]

DAPRADA M, 1988, EXPERIENTIA, V44, P115

[10] Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion? [J].

Debener, S ;

Strobel, A ;

Kürschner, K ;

Kranczioch, C ;

Hebenstreit, J ;

Maercker, A ;

Beauducel, A ;

Brocke, B .

BIOLOGICAL PSYCHOLOGY, 2002, 59 (02) :121-133

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