Inhibition of colonization and cell-matrix adhesion after nm23-H1 transfection of human prostate carcinoma cells

被引：34

作者：

Lim, SH ^{[1
]}

Lee, HY ^{[1
]}

Lee, HS ^{[1
]}

机构：

[1] Kangwon Natl Univ, Div Life Sci, Chunchon 200701, South Korea

来源：

CANCER LETTERS | 1998年 / 133卷 / 02期

关键词：

prostatic carcinoma; nm23; transfection; colonization; cell adhesion;

D O I：

10.1016/S0304-3835(98)00219-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A human gene, nm23-H1, has been known as a metastasis suppressor in many tumor cells. The cellular mechanisms by which the nm23-H1 protein may directly or indirectly modulate the metastatic phenotype are not yet known. In this study the phenotypic effect of transfection of nm23-H1 cDNA into the human DU 145 prostate carcinoma cell line was examined. Despite similar growth rates, the nm23-H1-transfected lines displayed decreased colonization in soft agar and adhesion to extracellular matrix components when compared with the control transfected Line. The results suggest that the nm23-H1 gene product suppresses the metastatic potential of prostate carcinoma cells by inhibiting their ability in anchorage-independent growth and extracellular matrix adhesion. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 149

页数：7

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