2021 marks a new era for Alzheimer's therapeutics

被引：10
作者：
Kantarci, Kejal [1 ]
机构：
[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA
来源：
LANCET NEUROLOGY | 2022年 / 21卷 / 01期
关键词：
D O I：
10.1016/S1474-4422(21)00412-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
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页码：3 / 4
页数：2
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  • [1] Cummings J, 2022, ALZHEIMERS DEMENT, V18, P531, DOI [10.1002/alz.12444, 10.14283/jpad.2021.41]
  • [2] NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
    Jack, Clifford R., Jr.
    Bennett, David A.
    Blennow, Kaj
    Carrillo, Maria C.
    Dunn, Billy
    Haeberlein, Samantha Budd
    Holtzman, David M.
    Jagust, William
    Jessen, Frank
    Karlawish, Jason
    Liu, Enchi
    Luis Molinuevo, Jose
    Montine, Thomas
    Phelps, Creighton
    Rankin, Katherine P.
    Rowe, Christopher C.
    Scheltens, Philip
    Siemers, Eric
    Snyder, Heather M.
    Sperling, Reisa
    Elliott, Cerise
    Masliah, Eliezer
    Ryan, Laurie
    Silverberg, Nina
    [J]. ALZHEIMERS & DEMENTIA, 2018, 14 (04) : 535 - 562
  • [3] Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays
    Leuzy, Antoine
    Janelidze, Shorena
    Mattsson-Carlgren, Niklas
    Palmqvist, Sebastian
    Jacobs, Dirk
    Cicognola, Claudia
    Stomrud, Erik
    Vanmechelen, Eugeen
    Dage, Jeffrey L.
    Hansson, Oskar
    [J]. NEUROLOGY, 2021, 97 (17) : E1681 - E1694
  • [4] APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
    Liu, Chia-Chen
    Murray, Melissa E.
    Li, Xia
    Zhao, Na
    Wang, Na
    Heckman, Michael G.
    Shue, Francis
    Martens, Yuka
    Li, Yonghe
    Raulin, Ana-Caroline
    Rosenberg, Cassandra L.
    Doss, Sydney, V
    Zhao, Jing
    Wren, Melissa C.
    Jia, Lin
    Ren, Yingxue
    Ikezu, Tadafumi C.
    Lu, Wenyan
    Fu, Yuan
    Caulfield, Thomas
    Trottier, Zachary A.
    Knight, Joshua
    Chen, Yixing
    Linares, Cynthia
    Wang, Xue
    Kurti, Aishe
    Asmann, Yan W.
    Wszolek, Zbigniew K.
    Smith, Glenn E.
    Vemuri, Prashanthi
    Kantarci, Kejal
    Knopman, David S.
    Lowe, Val J.
    Jack, Clifford R. Jr Jr
    Parisi, Joseph E.
    Ferman, Tanis J.
    Boeve, Bradley F.
    Graff-Radford, Neill R.
    Petersen, Ronald C.
    Younkin, Steven G.
    Fryer, John D.
    Wang, Hu
    Han, Xianlin
    Frieden, Carl
    Dickson, Dennis W.
    Ross, Owen A.
    Bu, Guojun
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (613)
  • [5] Donanemab in Early Alzheimer's Disease
    Mintun, Mark A.
    Lo, Albert C.
    Evans, Cynthia Duggan
    Wessels, Alette M.
    Ardayfio, Paul A.
    Andersen, Scott W.
    Shcherbinin, Sergey
    Sparks, JonDavid
    Sims, John R.
    Brys, Miroslaw
    Apostolova, Liana G.
    Salloway, Stephen P.
    Skovronsky, Daniel M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (18) : 1691 - 1704
  • [6] ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease
    Novak, Petr
    Kovacech, Branislav
    Katina, Stanislav
    Schmidt, Reinhold
    Scheltens, Philip
    Kontsekova, Eva
    Ropele, Stefan
    Fialova, Lubica
    Kramberger, Milica
    Paulenka-Ivanovova, Natalia
    Smisek, Miroslav
    Hanes, Jozef
    Stevens, Eva
    Kovac, Andrej
    Sutovsky, Stanislav
    Parrak, Vojtech
    Koson, Peter
    Prcina, Michal
    Galba, Jaroslav
    Cente, Martin
    Hromadka, Tomas
    Filipcik, Peter
    Piestansky, Juraj
    Samcova, Maria
    Prenn-Gologranc, Carmen
    Sivak, Roman
    Froelich, Lutz
    Fresser, Michal
    Rakusa, Martin
    Harrison, John
    Hort, Jakub
    Otto, Markus
    Tosun, Duygu
    Ondrus, Matej
    Winblad, Bengt
    Novak, Michal
    Zilka, Norbert
    [J]. NATURE AGING, 2021, 1 (06): : 521 - +
  • [7] Microglial activation and tau propagate jointly across Braak stages
    Pascoal, Tharick A.
    Benedet, Andrea L.
    Ashton, Nicholas J.
    Kang, Min Su
    Therriault, Joseph
    Chamoun, Mira
    Savard, Melissa
    Lussier, Firoza Z.
    Tissot, Cecile
    Karikari, Thomas K.
    Ottoy, Julie
    Mathotaarachchi, Sulantha
    Stevenson, Jenna
    Massarweh, Gassan
    Scholl, Michael
    de Leon, Mony J.
    Soucy, Jean-Paul
    Edison, Paul
    Blennow, Kaj
    Zetterberg, Henrik
    Gauthier, Serge
    Rosa-Neto, Pedro
    [J]. NATURE MEDICINE, 2021, 27 (09) : 1592 - +
  • [8] Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study
    Thijssen, Elisabeth H.
    La Joie, Renaud
    Strom, Amelia
    Fonseca, Corrina
    Iaccarino, Leonardo
    Wolf, Amy
    Spina, Salvatore
    Allen, Isabel E.
    Cobigo, Yann
    Heuer, Hilary
    VandeVrede, Lawren
    Proctor, Nicholas K.
    Lago, Argentina Lario
    Baker, Suzanne
    Sivasankaran, Rajeev
    Kieloch, Agnieszka
    Kinhikar, Arvind
    Yu, Lili
    Valentin, Marie-Anne
    Jeromin, Andreas
    Zetterberg, Henrik
    Hansson, Oskar
    Mattsson-Carlgren, Niklas
    Graham, Danielle
    Blennow, Kaj
    Kramer, Joel H.
    Grinberg, Lea T.
    Seeley, William W.
    Rosen, Howard
    Boeve, Bradley F.
    Miller, Bruce L.
    Teunissen, Charlotte E.
    Rabinovici, Gil D.
    Rojas, Julio C.
    Dage, Jeffrey L.
    Boxer, Adam L.
    [J]. LANCET NEUROLOGY, 2021, 20 (09) : 739 - 752
  • [9] U.S. Food & Drug Administration, 2021, FDA GRANTS ACC APPR
  • [10] Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease
    Zalocusky, Kelly A.
    Najm, Ramsey
    Taubes, Alice L.
    Hao, Yanxia
    Yoon, Seo Yeon
    Koutsodendris, Nicole
    Nelson, Maxine R.
    Rao, Antara
    Bennett, David A.
    Bant, Jason
    Amornkul, Dah-eun J.
    Xu, Qin
    An, Alice
    Cisne-Thomson, Olga
    Huang, Yadong
    [J]. NATURE NEUROSCIENCE, 2021, 24 (06) : 786 - 798
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