Circulating miR-19a-3p and miR-483-5p as Novel Diagnostic Biomarkers for the Early Diagnosis of Gastric Cancer

被引:27
作者
Cheng, Jieyao [1 ]
Yang, Aiming [1 ]
Cheng, Shujun [2 ]
Feng, Lin [2 ]
Wu, Xi [1 ]
Lu, Xinghua [1 ]
Zu, Ming [1 ]
Cui, Jianfang [1 ]
Yu, Hang [1 ]
Zou, Long [1 ]
机构
[1] Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Dept Etiol & Carcinogenesis,State Key Lab Mol Onc, Beijing, Peoples R China
来源
MEDICAL SCIENCE MONITOR | 2020年 / 26卷
关键词
Biological Markers; MicroRNAs; Precancerous Conditions; Stomach Neoplasms; MIRNA-34A; MIR-214; PATHWAY;
D O I
10.12659/MSM.923444
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: MicroRNAs (miRNAs) are attracting substantial interest as promising noninvasive biomarkers for gastric cancer (GC). Our study aimed to identify circulating miRNAs that are potential noninvasive markers for precancerous lesions and early gastric cancers (EGCs). Material/Methods: Plasma specimens were obtained from 58 gastritis subjects, 54 patients with precancerous lesions, and 38 EGC patients for study. Results: Significant differences in the plasma expression levels of miR-19a-3p, miR-22-3p, miR-146a-5p, and miR-483-5p (all P<0.05) were observed between EGC patients and gastritis subjects. Multivariable analysis showed that age (OR, 1.054; 95% CI, 1.006-1.104), miR-19a-3p expression (OR, 3.676; 95% CI, 1.914-7.061), and miR-483-5p expression (OR, 1.589; 95% CI, 1.242-2.033) were independently associated with EGCs and precancerous lesions. A combined diagnostic model incorporating these 3 variables for the prediction of EGCs and precancerous lesions was derived. The area under the receiver operating characteristic curve (AUC) of the model was 0.84; the sensitivity was 87.7% and the specificity was 62.8% at the cutoff value of -0.08. Conclusions: Plasma miR-19a-3p and miR-483-5p are promising and powerful noninvasive markers for the early detection of GC. Patients are more willing to undergo noninvasive diagnostic procedures than gastroscopy for cancer screening, economizing limited medical resources.
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页数:8
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