Brief Cognitive Tests for Distinguishing Clinical Alzheimer-Type Dementia From Mild Cognitive Impairment or Normal Cognition in Older Adults With Suspected Cognitive Impairment A Systematic Review

被引：41

作者：

Hemmy, Laura S. ^{[1
,3
]}

Linskens, Eric J. ^{[1
]}

Silverman, Pombie C. ^{[4
,8
]}

Miller, Margaret A. ^{[1
]}

Talley, Kristine M. C. ^{[5
]}

Taylor, Brent C. ^{[2
,3
]}

Ouellette, Jeannine M. ^{[6
]}

Greer, Nancy L. ^{[2
]}

Wilt, Timothy J. ^{[2
,3
]}

Butler, Mary ^{[7
]}

Fink, Howard A. ^{[1
,3
]}

机构：

[1] Minneapolis Vet Affairs Hlth Care Syst, Geriatr Res Educ & Clin Ctr, 11-G,One Vet Dr, Minneapolis, MN 55417 USA

[2] Minneapolis Vet Affairs Hlth Care Syst, Ctr Care Delivery & Outcomes Res, 111-0,One Vet Dr, Minneapolis, MN 55417 USA

[3] Univ Minnesota, Minneapolis, MN USA

[4] Minneapolis Vet Affairs Hlth Care Syst, Minneapolis, MN USA

[5] Univ Minnesota, Sch Nursing, 5-140 Weaver Densford Hall, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Div Hlth Policy & Management, Sch Publ Hlth, MMC 197,D330-6 Mayo Mem Bldg, Minneapolis, MN 55455 USA

[7] Univ Minnesota, Div Hlth Policy & Management, Sch Publ Hlth, MMC 729,D381 Mayo Mem Bldg, Minneapolis, MN 55455 USA

[8] Univ Iowa, Carver Coll Med, 375 Newton Rd, Iowa City, IA 52246 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2020年 / 172卷 / 10期

基金：

美国医疗保健研究与质量局;

关键词：

MINI-MENTAL-STATE; CLOCK DRAWING TEST; SERVICES TASK-FORCE; DIAGNOSTIC UTILITY; DETECTING DEMENTIA; VERBAL FLUENCY; LOGICAL MEMORY; SCREENING-TEST; UNITED-STATES; RATING-SCALE;

D O I：

10.7326/M19-3889

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The accuracy and harms of brief cognitive tests for identifying clinical Alzheimer-type dementia (CATD) are uncertain. Purpose: To summarize evidence on accuracy and harms of brief cognitive tests for CATD in older adults with suspected cognitive impairment. Data Sources: Electronic bibliographic databases (from inception to November 2019) and systematic review bibliographies. Study Selection: English-language, controlled observational studies in older adults that evaluated the accuracy of brief cognitive tests (standalone tests; memory, executive function, and language tests; and brief multidomain batteries) for distinguishing CATD from mild cognitive impairment (MCI) or normal cognition as defined by established diagnostic criteria. Studies with low or medium risk of bias (ROB) were analyzed. Data Extraction: Two reviewers rated ROB. One reviewer extracted data; the other verified extraction accuracy. Data Synthesis: Fifty-seven studies met analysis criteria. Many brief, single cognitive tests were highly sensitive and specific for distinguishing CATD from normal cognition. These included standalone tests (clock-drawing test, median sensitivity 0.79 and specificity 0.88 [8 studies]; Mini-Mental State Examination, 0.88 and 0.94 [7 studies]; Montreal Cognitive Assessment, 0.94 and 0.94 [2 studies]; and Brief Alzheimer Screen, 0.92 and 0.97 [1 study]), memory tests (list delayed recall, 0.89 and 0.94 [5 studies]), and language tests (category fluency, 0.92 and 0.89 [9 studies]). Accuracy was lower in distinguishing mild CATD from normal cognition and distinguishing CATD from MCI. No studies reported on testing harms. Limitations: Studies were small. Few test metrics were evaluated by multiple studies. Few studies directly compared different tests, scores, cut points, or test combinations. Conclusion: Many brief, single cognitive tests accurately distinguish CATD from normal cognition in older adults but are less accurate in distinguishing mild CATD from normal cognition or CATD from MCI. No studies reported on testing harms.

引用

页码：678 / +

页数：15

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