Remote difunctionalization of 2H-indazoles using Koser's reagents

被引：18

作者：

Bhattacharjee, Suvam ^{[1
]}

Laru, Sudip ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 07期

关键词：

N BOND FORMATION; C-H BOND; HYPERVALENT IODINE; FUNCTIONALIZATION; CYCLIZATION; CHEMISTRY; PYRAZOLES;

D O I：

10.1039/d1cc06129a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new, efficient, and metal-free protocol has been developed for remote difunctionalization of unreactive C-H bonds at the benzene core of 2H-indazole by employing Koser's reagents, which act as both sulfonyloxylating and iodinating agents under ambient air. The present methodology represents facile access to C-4-sulfonyloxylated and C-7-iodinated 2H-indazole derivatives with high regioselectivity, wide functional group tolerance, and broad substrate scope in good to excellent yields. The formed 4,7 disubstituted 2H-indazoles are the precursors of various C-4,7-functionalized 2H-indazoles through simple transformations.

引用

页码：981 / 984

页数：4

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