Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells

被引：6
作者：
Krief, Bryan [1 ,2 ]
Algor, Shira Weisthal [1 ,2 ]
Nakdimon, Itay [1 ,2 ]
Elhikis, Ayala [1 ,2 ]
Benhamou, Moshe [1 ,2 ]
Kadmon, Anouk Savir [1 ,2 ]
Keren, Shay [1 ,2 ]
Ohana, Oded [1 ,2 ]
Feldman, Ilan [1 ,2 ]
Ben Cnaan, Ran [1 ,2 ]
Leibovitch, Igal [1 ,2 ]
Loewenstein, Anat [1 ,2 ]
Barak, Adiel [1 ,2 ]
Barzelay, Aya [1 ,2 ]
机构：
[1] Tel Aviv Sourasky Med Ctr, Dept Ophthalmol, IL-6423906 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel
来源：
STEM CELLS INTERNATIONAL | 2021年 / 2021卷
关键词：
PIGMENT EPITHELIUM; SODIUM IODATE; MACULAR DEGENERATION; RPE CELLS; EXPRESSION; DAMAGE; TISSUE; DIFFERENTIATION; REGENERATION; ENGRAFTMENT;
D O I：
10.1155/2021/7022247
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Retinal degenerative diseases are one of the main causes of complete blindness in aged population. In this study, we compared the therapeutic potential for retinal degeneration of human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or from orbital fat (OASCs) due to their accessibility and mutual embryonic origin with retinal tissue, respectively. OASCs were found to protect RPE cells from cell death and were demonstrated to increase early RPE precursor markers, while ABASCs showed a raise in retinal precursor marker expression. Subretinal transplantation of OASCs in a mouse model of retinal degeneration led to restoration of the RPE layer while transplantation of ABASCs resulted in a significant restoration of the photoreceptor layer. Taken together, we demonstrated a lineage-specific therapeutic effect for either OASCs or ABASCs in retinal regeneration.
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页数：15
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