Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

被引：518
作者：
Moeini, Arash [1 ]
Pedram, Parisa [2 ,3 ]
Makvandi, Pooyan [4 ,5 ]
Malinconico, Mario [4 ]
d'Ayala, Giovanna Gomez [4 ]
机构：
[1] Univ Naples Federico II, Dept Chem Sci, Naples, Italy
[2] Univ Naples Federico II, Dept Chem Mat Ind Prod Engn, Naples, Italy
[3] IIT, CRIB, Ctr Adv Biomat Healthcare, Naples, Italy
[4] CNR, Inst Polymers Composites & Biomat, Rome, Italy
[5] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran
来源：
CARBOHYDRATE POLYMERS | 2020年 / 233卷
关键词：
Chitosan; Wound dressing; Natural compounds; Wound healing; Antimicrobial; TEA TREE OIL; CROSS-LINKING; ANTIBACTERIAL ACTIVITY; ALPHA-TOCOPHEROL; HYDROGEL FILMS; DRUG-DELIVERY; IN-VITRO; CHEMICAL-MODIFICATION; ANTIOXIDANT ACTIVITY; BACTERIAL CELLULOSE;
D O I：
10.1016/j.carbpol.2020.115839
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Wound healing can lead to complex clinical problems, hence finding an efficient approach to enhance the healing process is necessary. An ideal wound dressing should treat wounds at reasonable costs, with minimal inconveniences for the patient. Chitosan is one of the most investigated biopolymers for wound healing applications due to its biocompatibility, biodegradability, non-toxicity, and antimicrobial activity. Moreover, chitosan and its derivative have attracted numerous attentions because of the accelerating wound healing, and easy processability into different forms (gels, foams, membranes, and beads). All these properties make chitosanbased materials particularly versatile and promising for wound dressings. Besides, secondary natural metabolites could potentially act like the antimicrobial and anti-inflammatory agents and accelerate the healing process. This review collected almost all studies regarding natural compounds applications in wound healing by focusing on the chitosan-based bioactive wound dressing systems. An accurate analysis of different chitosan formulations and the influence of bioactive compounds on their wound healing properties are reported.
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页数：16
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