An Unexpected Phosphine-Catalyzed Regio- and Diastereoselective [4+1] Annulation Reaction of Modified Allylic Compounds with Activated Enones

被引：120

作者：

Chen, Zuliang ^{[1
]}

Zhang, Junliang ^{[1
,2
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2010年 / 5卷 / 07期

关键词：

annulation reactions; diastereoselectivity; dihydrofurans; enynes; phosphines; BAYLIS-HILLMAN REACTION; ONE-POT SYNTHESIS; NUCLEOPHILIC-ADDITION; GAMMA-BUTENOLIDES; ACETATES; ALLENES; CARBON; CYCLOADDITIONS; CONSTRUCTION; IMINES;

D O I：

10.1002/asia.201000193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In summary, we have discovered an unexpected phosphinecatalyzed regio-and diastereoselective [4+1] annulation reaction of readily available Morita-Baylis-Hillman carbonates and activated enones, which provided a simple, efficient, and practical method for the synthesis of highly functionalized 2,3-dihydrofurans. Further studies will focus on the development of related organocatalytic transformations of activated enones, as well as synthetic applications of the functionalized 2,3-dihydrofurans. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1542 / 1545

页数：4

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