An Unexpected Phosphine-Catalyzed Regio- and Diastereoselective [4+1] Annulation Reaction of Modified Allylic Compounds with Activated Enones

被引：118
|
作者：
Chen, Zuliang [1 ]
Zhang, Junliang [1 ,2 ]
机构：
[1] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2010年 / 5卷 / 07期
关键词：
annulation reactions; diastereoselectivity; dihydrofurans; enynes; phosphines; BAYLIS-HILLMAN REACTION; ONE-POT SYNTHESIS; NUCLEOPHILIC-ADDITION; GAMMA-BUTENOLIDES; ACETATES; ALLENES; CARBON; CYCLOADDITIONS; CONSTRUCTION; IMINES;
D O I：
10.1002/asia.201000193
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In summary, we have discovered an unexpected phosphinecatalyzed regio-and diastereoselective [4+1] annulation reaction of readily available Morita-Baylis-Hillman carbonates and activated enones, which provided a simple, efficient, and practical method for the synthesis of highly functionalized 2,3-dihydrofurans. Further studies will focus on the development of related organocatalytic transformations of activated enones, as well as synthetic applications of the functionalized 2,3-dihydrofurans. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1542 / 1545
页数：4
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