Synthesis and antiviral evaluation of α-D-2′,3′-didehydro-2′,3′-dideoxy-3′-C-hydroxymethyl nucleosides

被引：3

作者：

Yamada, Kohei ^{[1
]}

Hayakawa, Hiroyuki ^{[1
]}

Sakata, Shinji ^{[1
]}

Ashida, Noriyuki ^{[1
]}

Yoshimura, Yuichi ^{[2
]}

机构：

[1] Yamasa Corp, Div Biochem, Chiba 2880056, Japan

[2] Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 20期

关键词：

Nucleosides; Antiviral; S(N)2 ' Reaction; PYRIMIDINE NUCLEOSIDES; ALTERNATIVE SYNTHESIS; BIOLOGICAL-ACTIVITIES; ALLYLIC SELENIDES; SUGAR MOIETY; NUCLEOTIDES; OXETANOCIN; HIV; AGENTS; ISONUCLEOSIDES;

D O I：

10.1016/j.bmcl.2010.08.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-alpha-nucleosides. By applying the method, we have synthesized alpha-D-2',3'-didehydro-2',3'-dideoxy- 3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6013 / 6016

页数：4

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