Dynamics of Renin, Angiotensin II, and Angiotensin (1-7) during Pregnancy and Predisposition to Hypertension-Associated Complications

被引：4

作者：

Khlestova, G. V. ^{[1
]}

Romanov, A. Yu. ^{[1
]}

Nizyaeva, N. V. ^{[1
]}

Karapetyan, A. O. ^{[1
]}

Baev, O. R. ^{[1
,2
]}

Ivanets, T. Yu. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, VI Kulakov Natl Med Res Ctr Obstet Gynecol & Peri, Moscow, Russia

[2] IM Sechenov First Moscow State Med Univ, Minist Hlth Russian Federat, Fac Postgrad Profess Educ, Dept Obstet Gynecol Perinatol & Reproductol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 04期

关键词：

angiotensin II; angiotensin (1-7); pregnancy; renin; renin-angiotensin-aldosterone system; ALDOSTERONE SYSTEM; PREECLAMPSIA; DISEASES; OUTCOMES;

D O I：

10.1007/s10517-018-4188-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in the levels of rennin, angiotensin II, and angiotensin (1-7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7 +/- 1.2 to 14.7 +/- 1.9 pg/ml (p=0.019). On the contrary, angiotensin (1-7) concentration decreased from 771.1 +/- 44.2 to 390.7 +/- 13.9 pg/ml (p < 0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1-7) attests to high predisposition of pregnant women to hypertension-related complications.

引用

页码：438 / 439

页数：2

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