Role of ghrelin in pancreatic development and function

被引：19

作者：

Napolitano, Tiziana ^{[1
,2
]}

Silvano, Serena ^{[1
,2
]}

Vieira, Andhira ^{[1
,2
]}

Balaji, Shruti ^{[1
,2
]}

Garrido-Utrilla, Anna ^{[1
,2
]}

Friano, Marika E. ^{[1
,2
]}

Atlija, Josipa ^{[1
,2
]}

Collombat, Patrick ^{[1
,2
]}

机构：

[1] Univ Nice Sophia Antipolis, INSERM, CNRS, iBV, F-06100 Nice, France

[2] Univ Nice Sophia Antipolis, Ctr Biochim, Inst Biol Valrose, iBV, Nice 2, France

来源：

DIABETES OBESITY & METABOLISM | 2018年 / 20卷

基金：

欧洲研究理事会;

关键词：

ghrelin; pancreas; glucose homeostasis; insulin; diabetes; CENTRAL-NERVOUS-SYSTEM; ENDOCRINE CELL-TYPE; LOW PLASMA GHRELIN; INSULIN-SECRETION; BETA-CELLS; ACYLATED GHRELIN; NEUROPEPTIDE-Y; FOOD-INTAKE; NONACYLATED GHRELIN; CIRCULATING GHRELIN;

D O I：

10.1111/dom.13385

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intake and energy expenditure. Besides its central activity, ghrelin is also involved in the regulation of pancreatic development and physiology. Particularly, several studies highlighted the ability of ghrelin to sustain beta-cell viability and proliferation. Furthermore, ghrelin seems to exert inhibitory effects on pancreatic acinar and endocrine secretory functions. Due to its pleiotropic activity on energy metabolism, ghrelin has become a topic of great interest for experimental research focused on type II diabetes and obesity. The aim of this review is to illustrate the complex and not fully understood interplay between ghrelin, pancreas and glucose homeostasis.

引用

页码：3 / 10

页数：8

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