What is amphidinolide V?: Report on a likely conquest

被引：68

作者：

Fuerstner, Alois ^{[1
]}

Larionov, Oleg ^{[1
]}

Fluegge, Susanne ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 29期

关键词：

alkynes; macrolides; metathesis; natural products; structure elucidation;

D O I：

10.1002/anie.200701640

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The awesome power of metathesis is reflected in the synthesis of the proposed structure of the cytotoxic natural product amphidinolide V, as well as of all other stereomers containing a trans-epoxide unit. It can be concluded from the comprehensive data set obtained that the 8S,9R,10R,13S-configured compound 1 most likely represents amphidinolide V, even though a single resonance in the 1H NMR spectrum deviates from the reported value. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5545 / 5548

页数：4

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