IL-10 Restricts Memory T Cell Inflation during Cytomegalovirus Infection

被引：46

作者：

Jones, Morgan ^{[1
]}

Ladell, Kristin ^{[1
]}

Wynn, Katherine K. ^{[1
]}

Stacey, Maria A. ^{[1
]}

Quigley, Maire F. ^{[1
]}

Gostick, Emma ^{[1
]}

Price, David A. ^{[1
]}

Humphreys, Ian R. ^{[1
]}

机构：

[1] Cardiff Univ, Dept Infect Immun & Biochem, Sch Med, Cardiff CF14 4XN, S Glam, Wales

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

CHRONIC VIRAL-INFECTION; ALLOGENEIC BONE-MARROW; NECROSIS-FACTOR-ALPHA; MURINE CYTOMEGALOVIRUS; TRANSCRIPTIONAL REACTIVATION; HUMAN INTERLEUKIN-10; ADOPTIVE TRANSFER; INTERFERON-GAMMA; RESPONSES; REPLICATION;

D O I：

10.4049/jimmunol.1001535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The beta-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. In this paper, we report that this expansion, or "inflation," of memory T cells is amplified dramatically during mouse CMV infection of IL-10 knockout (IL-10(-/-)) mice. T cells from IL-10(-/-) mice were oligoclonal, exhibited a highly activated phenotype, expressed antiviral cytokines, and degranulated in response to cognate Ag encounter ex vivo. Moreover, latent viral load was reduced in IL-10(-/-) mice. Importantly, these results were recapitulated by IL-10R blockade during chronic/latent infection of wild-type mice. These data demonstrate that regulatory immune mechanisms can influence CMV-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses. The Journal of Immunology, 2010, 185: 3583-3592.

引用

页码：3583 / 3592

页数：10

共 85 条

[1] CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis [J].

Anderson, Charles F. ;

Oukka, Mohammed ;

Kuchroo, Vijay J. ;

Sacks, David .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :285-297

[2] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections [J].

Appay, V ;

Dunbar, PR ;

Callan, M ;

Klenerman, P ;

Gillespie, GMA ;

Papagno, L ;

Ogg, GS ;

King, A ;

Lechner, F ;

Spina, CA ;

Little, S ;

Havlir, DV ;

Richman, DD ;

Gruener, N ;

Pape, G ;

Waters, A ;

Easterbrook, P ;

Salio, M ;

Cerundolo, V ;

McMichael, AJ ;

Rowland-Jones, SL .

NATURE MEDICINE, 2002, 8 (04) :379-385

[3] Murine cytomegalovirus induces a polyfunctional CD4 T cell response [J].

Arens, Ramon ;

Wang, Peng ;

Sidney, John ;

Loewendorf, Andrea ;

Sette, Alessandro ;

Schoenberger, Stephen P. ;

Peters, Bjoern ;

Benedict, Chris A. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (10) :6472-6476

[4] Properties of murine CD8+CD27- T cells [J].

Baars, PA ;

Sierro, S ;

Arens, R ;

Tesselaar, K ;

Hooibrink, B ;

Klenerman, P ;

van Lier, RAW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (11) :3131-3141

[5] A lymphotoxin-IFN-β axis essential for lymphocyte survival revealed during cytomegalovirus infection [J].

Banks, TA ;

Rickert, S ;

Benedict, CA ;

Ma, L ;

Ko, M ;

Meier, J ;

Ha, W ;

Schneider, K ;

Granger, SW ;

Turovskaya, O ;

Elewaut, D ;

Otero, D ;

French, AR ;

Henry, SC ;

Hamilton, JD ;

Scheu, S ;

Pfeffer, K ;

Ware, CF .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :7217-7225

[6] Herpesvirus latency confers symbiotic protection from bacterial infection [J].

Barton, Erik S. ;

White, Douglas W. ;

Cathelyn, Jason S. ;

Brett-McClellan, Kelly A. ;

Engle, Michael ;

Diamond, Michael S. ;

Miller, Virginia L. ;

Virgin, Herbert W. .

NATURE, 2007, 447 (7142) :326-U7

[7] Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice [J].

Bedoret, Denis ;

Wallemacq, Hugues ;

Marichal, Thomas ;

Desmet, Christophe ;

Calvo, Florence Quesada ;

Henry, Emmanuelle ;

Closset, Rodrigue ;

Dewals, Benjamin ;

Thielen, Caroline ;

Gustin, Pascal ;

de Leval, Laurence ;

Van Rooijen, Nico ;

Le Moine, Alain ;

Vanderplasschen, Alain ;

Cataldo, Didier ;

Drion, Pierre-Vincent ;

Moser, Muriel ;

Lekeux, Pierre ;

Bureau, Fabrice .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) :3723-3738

[8] Interleukin-10 determines viral clearance or persistence in vivo [J].

Brooks, David G. ;

Trifilo, Matthew J. ;

Edelmann, Kurt H. ;

Teyton, Luc ;

McGavern, Dorian B. ;

Oldstone, Michael B. A. .

NATURE MEDICINE, 2006, 12 (11) :1301-1309

[9] The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression [J].

Chattopadhyay, Pratip K. ;

Betts, Michael R. ;

Price, David A. ;

Gostick, Emma ;

Horton, Helen ;

Roederer, Mario ;

De Rosa, Stephen C. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 85 (01) :88-97

[10] The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency [J].

Cheung, Allen K. L. ;

Gottlieb, David J. ;

Plachter, Bodo ;

Pepperl-Klindworth, Sandra ;

Avdic, Selmir ;

Cunningham, Anthony L. ;

Abendroth, Allison ;

Slobedman, Barry .

BLOOD, 2009, 114 (19) :4128-4137

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