Homonuclear dinickel complexes: structural mimics for the dinickel subsite of the A-cluster of acetyl-CoA synthase

被引：22
作者：
Duff, SE [1 ]
Barclay, JE [1 ]
Davies, SC [1 ]
Evans, DJ [1 ]
机构：
[1] John Innes Ctr, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2005年 / 8卷 / 02期
关键词：
nickel complexes; acetyl-CoA synthase; bioinorganic chemistry;
D O I：
10.1016/j.inoche.2004.11.026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
[Ni(ema)(p-S,S')Ni(dppp)] (1) and [Ni(ema)(mu-S,S')Ni(dppe)] (2) have been prepared as synthetic structural analogues of the Ni-Ni subsite of the A-cluster of the enzyme acetyl-CoA synthase by reaction of [Ni(ema)](2-), H(4)ema is N,N'-ethylenebis(2-mercaptoacetamide), with [NiCl2(diphos)], diphos is 1,2-bis(diphenylphosphino)propane (dppp) or 1,2-bis(diphenylphosphino)ethane (dppe). A similar reaction with 1,2-bis(diethylphosphino)ethane did not give the dinuclear product but the trinuclear complex [NEt4](2)[Ni {Ni(ema)(mu-S,S')}(2)] (3). Complexes 1 and 3 have been crystallographically characterised. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：170 / 173
页数：4
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