Molecular Mechanisms of Diabetic Kidney Disease

被引：56

作者：

Rico-Fontalvo, Jorge ^{[1
,2
]}

Aroca, Gustavo ^{[1
,3
]}

Cabrales, Jose ^{[4
]}

Daza-Arnedo, Rodrigo ^{[1
]}

Yanez-Rodriguez, Tomas ^{[5
]}

Martinez-Avila, Maria Cristina ^{[6
]}

Uparella-Gulfo, Isabella ^{[7
]}

Raad-Sarabia, Maria ^{[8
]}

机构：

[1] Colombian Nephrol Assoc, Bogota 110221, Colombia

[2] Univ Simon Bolivar, Dept Engn, Management Technol & Innovat, Cl 58 55-132, Barranquilla 080002, Colombia

[3] Univ Simon Bolivar, Fac Med, Barranquilla 080002, Colombia

[4] Stanford Univ, Sch Med, Palo Alto, CA 94305 USA

[5] Univ Cartagena, Internal Med, Cartagena 130001, Colombia

[6] Univ Cartagena, BIOTOXAM Grp, Cartagena 130001, Colombia

[7] Univ Sinu, Gen Med, Cartagena 130015, Colombia

[8] Univ Sinu, Internal Med, Cartagena 130015, Colombia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 15期

关键词：

genetics; epigenetic; inflammatory; innate; adaptive; cytokines; innovation; STAGE RENAL-DISEASE; SERUM CONCENTRATIONS; AMERICAN-INDIANS; BINDING-PROTEIN; URINARY KIM-1; BIOMARKERS; MORTALITY; MARKERS; INJURY; INFLAMMATION;

D O I：

10.3390/ijms23158668

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inflammatory component of diabetic kidney disease has become of great interest in recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components such as the complement system also play a role, as well as specific cytokines and chemokines. The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets.

引用

页数：16

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