Modified Glasgow Prognostic Score and Carcinoembryonic Antigen Predict Poor Prognosis in Elderly Patients with Colorectal Cancer

被引：7
|
作者：
Numata, Koji [1 ]
Ono, Yukari [1 ]
Toda, Soji [1 ]
Kamioka, Yuto [1 ]
Suematsu, Hideaki [1 ]
Sawazaki, Sho [1 ]
Tsuchida, Kazuhito [1 ]
Higuchi, Akio [1 ]
Saeki, Hiroyuki [1 ]
Rino, Yasushi [2 ]
Masuda, Munetaka [2 ]
Matsukawa, Hiroshi [1 ]
机构：
[1] Yokohama Minami Kyosai Hosp, Dept Surg, Yokohama, Kanagawa, Japan
[2] Yokohama City Univ, Dept Surg, Yokohama, Kanagawa, Japan
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2020年 / 43卷 / 04期
关键词：
Colorectal cancer; Modified Glasgow Prognostic Score; Elderly; Curative surgery; SURVIVAL; GPS; COLON;
D O I：
10.1159/000505930
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To investigate the prognostic values of the preoperative modified Glasgow Prognostic Score (mGPS) and carcinoembryonic antigen (CEA) alone and combined in elderly patients with colorectal cancer (CRC) planning to receive curative surgery. Methods: We retrospectively analyzed 130 elderly patients (aged >= 80 years) with CRC who received curative surgery between 2008 and 2016. The preoperative mGPS and CEA levels were calculated. Results: Elevated preoperative mGPS or CEA level was significantly associated with shorter relapse-free survival (p = 0.005, both) and cancer-specific survival (p = 0.011 and p < 0.001, respectively). Combined use of these two factors improved the predictive accuracy for tumor recurrence relative to that of either factor. Conclusion: Both mGPS and CEA were independent prognostic factors of CRC in elderly patients receiving curative surgery, but their combination was more accurate.
引用
收藏
页码：125 / 132
页数：7
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