Management of toxic epidermal necrolysis and related syndromes

被引：26

作者：

Mukasa, Y. ^{[1
]}

Craven, N. ^{[1
]}

机构：

[1] Macclesfield Hosp, Dept Dermatol, Macclesfield, Cheshire, England

来源：

POSTGRADUATE MEDICAL JOURNAL | 2008年 / 84卷 / 988期

关键词：

D O I：

10.1136/pgmj.2007.061465

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare and life-threatening diseases that often configure as medical emergencies. The majority of cases are drug reactions. The clinical picture is one of widespread epidermal necrosis and mucosal erosions. Treatment is largely supportive and must be provided in an appropriate environment. The role of steroids and other potential disease-modifying therapies has yet to be fully established by controlled studies. The significant mortality associated with these conditions dictates that an understanding of these conditions is essential for all doctors.

引用

页码：60 / 65

页数：6

共 41 条

[1] Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligand [J].

Abe, R ;

Shimizu, T ;

Shibaki, A ;

Nakamura, H ;

Watanabe, H ;

Shimizu, H .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (05) :1515-1520

[2]

Arévalo JM, 2000, J TRAUMA, V48, P473

[3] ERYTHEMA MULTIFORME WITH MUCOUS-MEMBRANE INVOLVEMENT AND STEVENS-JOHNSON SYNDROME ARE CLINICALLY DIFFERENT DISORDERS WITH DISTINCT CAUSES [J].

ASSIER, H ;

BASTUJIGARIN, S ;

REVUZ, J ;

ROUJEAU, JC .

ARCHIVES OF DERMATOLOGY, 1995, 131 (05) :539-543

[4] Intravenous immunoglobulin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis - A prospective noncomparative study showing no benefit on mortality or progression [J].

Bachot, N ;

Revuz, J ;

Roujeau, JC .

ARCHIVES OF DERMATOLOGY, 2003, 139 (01) :33-36

[5] SCORTEN: A severity-of-illness score for toxic epidermal necrolysis [J].

Bastuji-Garin, S ;

Fouchard, N ;

Bertocchi, M ;

Roujeau, JC ;

Revuz, J ;

Wolkenstein, P .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (02) :149-153

[6] CLINICAL CLASSIFICATION OF CASES OF TOXIC EPIDERMAL NECROLYSIS, STEVENS-JOHNSON SYNDROME, AND ERYTHEMA MULTIFORME [J].

BASTUJIGARIN, S ;

RZANY, B ;

STERN, RS ;

SHEAR, NH ;

NALDI, L ;

ROUJEAU, JC .

ARCHIVES OF DERMATOLOGY, 1993, 129 (01) :92-96

[7] The CD40/CD40 ligand system is expressed in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum [J].

Caproni, M ;

Torchia, D ;

Schincaglia, E ;

Volpi, W ;

Frezzolini, A ;

Schena, D ;

Marzano, A ;

Quaglino, P ;

Simone, C ;

Parodi, A ;

Barletta, E ;

Fabbri, P .

BRITISH JOURNAL OF DERMATOLOGY, 2006, 154 (02) :319-324

[8] Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis [J].

Egan, CA ;

Grant, WJ ;

Morris, SE ;

Saffle, JR ;

Zone, JJ .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (03) :458-461

[9] FAMILIAL OCCURRENCE OF STEVENS-JOHNSON SYNDROME [J].

FISCHER, PR ;

SHIGEOKA, AO .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1983, 137 (09) :914-916

[10] INVESTIGATION OF MECHANISMS IN TOXIC EPIDERMAL NECROLYSIS INDUCED BY CARBAMAZEPINE [J].

FRIEDMANN, PS ;

STRICKLAND, I ;

PIRMOHAMED, M ;

PARK, BK .

ARCHIVES OF DERMATOLOGY, 1994, 130 (05) :598-604

← 1 2 3 4 5 →