Pumilacidins from the Octocoral-Associated Bacillus sp DT001 Display Anti-Proliferative Effects in Plasmodium falciparum

被引：9
作者：
Torres-Mendoza, Daniel [1 ,2 ]
Coronado, Lorena M. [3 ]
Pineda, Laura M. [3 ]
Guzman, Hector M. [4 ]
Dorrestein, Pieter C. [5 ,6 ]
Spadafora, Carmenza [3 ]
Gutierrez, Marcelino [1 ]
机构：
[1] Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Ctr Biodiversidad & Descubrimiento Drogas, Apartado 0843-01103, Panama City, Panama
[2] Acharya Nagarjuna Univ, Dept Biotechnol, Nagarjuna Nagar 522510, Guntur, India
[3] INDICASAT AIP, Ctr Biol Celular & Mol Enfermedades, Apartado 0843-01103, Panama City, Panama
[4] Smithsonian Trop Res Inst, Ancon POB 0843-03092, Balboa, Panama
[5] Univ Calif San Diego, Collaborat Mass Spectrometry Innovat Ctr, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
[6] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
来源：
MOLECULES | 2018年 / 23卷 / 09期
关键词：
Bacillus; surfactins; pumilacidins; coral-associated bacteria; P; falciparum; apoptosis; PROGRAMMED CELL-DEATH; ANTIINFLAMMATORY ACTIVITY; SIGNAL-TRANSDUCTION; SURFACTIN; LIPOPEPTIDES; SURVIVAL; INDUCTION; APOPTOSIS; METABOLITES; MODULATION;
D O I：
10.3390/molecules23092179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.
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页数：17
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