Syntheses and identification of the most abundant urinary type VI isoprostanes

被引：12
作者：
Adiyaman, M
Lawson, JA
FitzGerald, GA
Rokach, J
机构：
[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA
[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA
[3] Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(98)01524-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of 8-12-iso-iPF(2 alpha) -VI 12 and its 5 epimer 13 is described. With the aid of the synthetic materials these isoprostanes have been identified in and isolated from human urine. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7039 / 7042
页数：4
相关论文
共 9 条
[1]   Total synthesis of a novel isoprostane IPF2 alpha-I and its identification in biological fluids [J].
Adiyaman, M ;
Lawson, JA ;
Hwang, SW ;
Khanapure, SP ;
FitzGerald, GA ;
Rokach, J .
TETRAHEDRON LETTERS, 1996, 37 (28) :4849-4852
[2]  
ADIYAMAN M, 1998, ANAL BIOCH
[3]   TOTAL SYNTHESIS OF 8-EPI-PGF(2-ALPHA) - A NOVEL STRATEGY FOR THE SYNTHESIS OF ISOPROSTANES [J].
HWANG, SW ;
ADIYAMAN, M ;
KHANAPURE, S ;
SCHIO, L ;
ROKACH, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (23) :10829-10830
[4]   Functional characterization of the ocular prostaglandin F-2 alpha (PGF(2 alpha)) receptor - Activation by the isoprostane, 12-iso-PGF(2 alpha) [J].
Kunapuli, P ;
Lawson, JA ;
Rokach, J ;
FitzGerald, GA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) :27147-27154
[5]   IPF2α-I:: An index of lipid peroxidation in humans [J].
Praticò, D ;
Barry, OP ;
Lawson, JA ;
Adiyaman, M ;
Hwang, SW ;
Khanapure, SP ;
Iuliano, L ;
Rokach, J ;
FitzGerald, GA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3449-3454
[6]   The generation and actions of isoprostanes [J].
Roberts, LJ ;
Morrow, JD .
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1997, 1345 (02) :121-135
[7]  
Rokach J, 1998, SYNTHESIS-STUTTGART, P569
[8]   The isoprostanes: A perspective [J].
Rokach, J ;
Khanapure, SP ;
Hwang, SW ;
Adiyaman, M ;
Lawson, JA ;
FitzGerald, GA .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1997, 54 (06) :823-851
[9]   A FREE-RADICAL ROUTE TO SYN LACTONES AND OTHER PROSTANOID INTERMEDIATES IN ISOPROSTAGLANDIN SYNTHESIS [J].
RONDOT, B ;
DURAND, T ;
GIRARD, JP ;
ROSSI, JC ;
SCHIO, L ;
KHANAPURE, SP ;
ROKACH, J .
TETRAHEDRON LETTERS, 1993, 34 (51) :8245-8248
1