Efficiency in chemistry: from hydrogen autotransfer to multicomponent catalysis

被引：42

作者：

Alonso, Francisco ^{[1
,2
]}

Foubelo, Francisco ^{[1
,2
]}

Gonzalez-Gomez, Jose C. ^{[1
,2
]}

Martinez, Ricardo ^{[1
,2
]}

Ramon, Diego J. ^{[1
,2
]}

Riente, Paola ^{[1
,2
]}

Yus, Miguel ^{[1
,2
]}

机构：

[1] Univ Alicante, Inst Sintesis Organ, Fac Ciencias, E-03080 Alicante, Spain

[2] Univ Alicante, Dept Quim Organ, Fac Ciencias, E-03080 Alicante, Spain

来源：

MOLECULAR DIVERSITY | 2010年 / 14卷 / 03期

关键词：

Hydrogen autotransfer; Alcohols as electrophiles; Atom efficiency processes; Multicomponent catalysis; AZA-WITTIG REACTION; INDIRECT FRIEDLANDER SYNTHESIS; NICKEL NANOPARTICLES; CONJUGATE ADDITION; CARBONYL-COMPOUNDS; ALPHA-ALKYLATION; RUCL2(DMSO)(4) CATALYZES; ORGANOZINC REAGENTS; TRANSFER REDUCTION; PRIMARY ALCOHOLS;

D O I：

10.1007/s11030-009-9195-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hydrogen autotransfer reaction has been applied to the alpha-alkylation of ketones, with primary alcohols as the electrophilic component, either under homogeneous (using a Ru complex as catalyst) or under heterogeneous (using Ni nanoparticles) conditions. This process is both very efficient (concerning atom economy) and ecologically friendly (water as the only by-product generated). On the other hand, three multicomponent reactions, namely, the Strecker reaction (without any catalyst), the aza-Sakurai process (catalyzed by ferrite), and the addition of in situ generated Zn enolates to chiral sulfinylimines (catalyzed by Cu), have proven to be very efficient in the generation of a diversity of polyfunctionalized molecules.

引用

页码：411 / 424

页数：14

共 49 条

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