ROR1 expression is not a unique marker of CLL

被引：59

作者：

Barna, Gabor ^{[1
]}

Mihalik, Rudolf ^{[1
,2
]}

Timar, Botond ^{[1
]}

Toemboel, Judit ^{[1
]}

Csende, Zsolt ^{[3
]}

Sebestyen, Anna ^{[1
]}

Boedoer, Csaba ^{[1
]}

Csernus, Balazs ^{[1
]}

Reiniger, Lilla ^{[1
]}

Petak, Istvan ^{[1
,2
]}

Matolcsy, Andras ^{[1
]}

机构：

[1] Semmelweis Univ, Fac Med, Dept Pathol & Expt Canc Res 1, H-1085 Budapest, Hungary

[2] Semmelweis Univ, Cooperat Res Ctr, H-1085 Budapest, Hungary

[3] Fac Med, Dept Biomech, Budapest, Hungary

来源：

HEMATOLOGICAL ONCOLOGY | 2011年 / 29卷 / 01期

关键词：

CLL; MCL; MZL; ROR1; Wnt; lymphoma; CHRONIC LYMPHOCYTIC-LEUKEMIA; RECEPTOR TYROSINE KINASE; GENE-EXPRESSION; HUMAN CANCER; B-CELLS; MUTATIONS; SCREEN; PROGRESSION; ACTIVATION; PHENOTYPE;

D O I：

10.1002/hon.948

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) on the surface of chronic lymphoid leukaemia (CLL) cells. In order to determine whether ROR1 expression is a suitable surrogate marker for the diagnosis of CLL we analysed the mRNA level of ROR1 in different types of non-Hodgkin lymphomas (NHL), and detected elevated levels of ROR1 compared to control peripheral mononuclear cells in several entities (CLL >= mantle cell lymphoma (MCL) > marginal zone lymphoma (MZL)>> diffuse large B-cell lymphoma > follicular lymphoma). ROR1 protein was expressed intensely on the cell surface of lymphoma cells with leukaemic blood count detected by three colour immunofluorescence. Our results indicate that ROR1 expression is not limited to CLL cases, but it is more prevalent in NHLs, mainly in MCL where it is expressed intensely and MZL where it is expressed moderately, suggesting a general role of ROR1 in lymphoma genesis and/or maintenance. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：17 / 21

页数：5

共 27 条

[1] Mutational analysis of the tyrosine kinome in colorectal cancers [J].

Bardelli, A ;

Parsons, DW ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Saha, S ;

Markowitz, S ;

Willson, JKV ;

Parmigiani, G ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2003, 300 (5621) :949-949

[2] Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia [J].

Baskar, Sivasubramanian ;

Kwong, Kayin ;

Hofer, Thomas ;

Levy, Jessica M. ;

Kennedy, Michael G. ;

Lee, Elinor ;

Staudt, Louis M. ;

Wilson, Wyndham H. ;

Wiestner, Adrian ;

Rader, Christoph .

CLINICAL CANCER RESEARCH, 2008, 14 (02) :396-404

[3] Systematic genomic screen for tyrosine kinase mutations in CLL [J].

Brown, J. R. ;

Levine, R. L. ;

Thompson, C. ;

Basile, G. ;

Gilliland, D. G. ;

Freedman, A. S. .

LEUKEMIA, 2008, 22 (10) :1966-1969

[4] Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy [J].

DaneshManesh, Amir H. ;

Mikaelsson, Eva ;

Jeddi-Tehrani, Mahmood ;

Bayat, Ali Ahmad ;

Ghods, Roya ;

Ostadkarampour, Mahyar ;

Akhondi, Mehdi ;

Lagercrantz, Svetlana ;

Larsson, Catharina ;

Osterborg, Anders ;

Shokri, Fazel ;

Mellstedt, Hakan ;

Rabbani, Hodjattallah .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (05) :1190-1195

[5] Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis [J].

Dosen, Guri ;

Tenstad, Ellen ;

Nygren, Marit Kveine ;

Stubberud, Heidi ;

Funderud, Steinar ;

Rian, Edith .

BMC IMMUNOLOGY, 2006, 7 (1)

[6] Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal,antigen and receptor for Wnt5a [J].

Fukuda, Tetsuya ;

Chen, Liguang ;

Endo, Tomoyuki ;

Tang, Li ;

Lu, Desheng ;

Castro, Jariuario E. ;

Widhopf, George F., II ;

Rassenti, Laura Z. ;

Cantwell, Mark J. ;

Prussak, Charles E. ;

Carson, Dennis A. ;

Kipps, Thomas J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) :3047-3052

[7] Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression [J].

Gagyi, Eva ;

Balogh, Zsofia ;

Boedoer, Csaba ;

Timar, Botond ;

Reiniger, Lilla ;

Deak, Linda ;

Csomor, Judit ;

Csernus, Balazs ;

Szepesi, Agota ;

Matolcsy, Andras .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (12) :1822-1828

[8] Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma [J].

Gelebart, Pascal ;

Anand, Mona ;

Armanious, Hanan ;

Peters, Anthea C. ;

Bard, Jennifer Dien ;

Amin, Hesham M. ;

Lai, Raymond .

BLOOD, 2008, 112 (13) :5171-5179

[9] Ror receptor tyrosine kinases: orphans no more [J].

Green, Jennifer L. ;

Kuntz, Steven G. ;

Sternberg, Paul W. .

TRENDS IN CELL BIOLOGY, 2008, 18 (11) :536-544

[10] Patterns of somatic mutation in human cancer genomes [J].

Greenman, Christopher ;

Stephens, Philip ;

Smith, Raffaella ;

Dalgliesh, Gillian L. ;

Hunter, Christopher ;

Bignell, Graham ;

Davies, Helen ;

Teague, Jon ;

Butler, Adam ;

Edkins, Sarah ;

O'Meara, Sarah ;

Vastrik, Imre ;

Schmidt, Esther E. ;

Avis, Tim ;

Barthorpe, Syd ;

Bhamra, Gurpreet ;

Buck, Gemma ;

Choudhury, Bhudipa ;

Clements, Jody ;

Cole, Jennifer ;

Dicks, Ed ;

Forbes, Simon ;

Gray, Kris ;

Halliday, Kelly ;

Harrison, Rachel ;

Hills, Katy ;

Hinton, Jon ;

Jenkinson, Andy ;

Jones, David ;

Menzies, Andy ;

Mironenko, Tatiana ;

Perry, Janet ;

Raine, Keiran ;

Richardson, Dave ;

Shepherd, Rebecca ;

Small, Alexandra ;

Tofts, Calli ;

Varian, Jennifer ;

Webb, Tony ;

West, Sofie ;

Widaa, Sara ;

Yates, Andy ;

Cahill, Daniel P. ;

Louis, David N. ;

Goldstraw, Peter ;

Nicholson, Andrew G. ;

Brasseur, Francis ;

Looijenga, Leendert ;

Weber, Barbara L. ;

Chiew, Yoke-Eng .

NATURE, 2007, 446 (7132) :153-158

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