Mechanisms of ketogenic diet action

Metabolic changes likely related to the anticonvulsant efficacy of the ketogenic diet include-but are not limited to-ketosis, reduced glucose, elevated fatty acid levels, and enhanced bioenergetic reserves. This review highlights the complex interrelationships between reduced seizures and metabolic adaptations that modulate neuronal excitability and may even afford neuroprotection. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.