Mechanisms of disease - When cilia go bad: cilia defects and ciliopathies

被引：935
作者：
Fliegauf, Manfred
Benzing, Thomas
Omran, Heymut [1 ]
机构：
[1] Univ Hosp Freiburg, Dept Paediat & Adolescent Med, D-79106 Freiburg, Germany
[2] Univ Cologne, Dept Med, D-50937 Cologne, Germany
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 11期
关键词：
D O I：
10.1038/nrm2278
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Defects in the function of cellular organelles such as peroxisomes, lysosomes and mitochondria are well-known causes of human diseases. Recently, another organelle has also been added to this list. Cilia-tiny hair-like organelles attached to the cell surface-are located on almost all polarized cell types of the human body and have been adapted as versatile tools forvarious cellular functions, explaining why cilia-related disorders can affect many organ systems. Several molecular mechanisms involved in cilia-related disorders have been identified that affect the structure and function of distinct cilia types.
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收藏
页码：880 / 893
页数：14
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