Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon

被引：12

作者：

Manouana, Gedeon Prince ^{[1
,2
]}

Maloum, Moustapha Nzamba ^{[1
]}

Bikangui, Rodrigue ^{[1
,3
]}

Bingono, Sam O'neilla Oye ^{[1
]}

Nguema, Georgelin Ondo ^{[1
]}

Honkpehedji, Josiane Yabo ^{[1
]}

Rossatanga, Elie Gide ^{[4
]}

Zoa-Assoumou, Samira ^{[5
,6
]}

Pallerla, Srinivas Reddy ^{[2
]}

Rachakonda, Sivaramakrishna ^{[2
]}

Mintsa, Armel Ndong ^{[5
]}

Lekana-Douki, Jean-Bernard ^{[7
]}

Siawaya, Joel-Fleury Djoba ^{[8
]}

Borrmann, Steffen ^{[1
,2
,9
]}

Kremsner, Peter Gottfried ^{[1
,2
,9
]}

Lell, Bertrand ^{[1
,2
,10
]}

Velavan, Thirumalaisamy P. ^{[2
,11
]}

Adegnika, Ayola Akim ^{[1
,2
,9
,12
]}

机构：

[1] Ctr Rech Med Lambarene, Lambarene, Gabon

[2] Univ Klin Tubingen, Inst Tropical Med, Tubingen, Germany

[3] Ecole Doctorale Franceville, Franceville, Gabon

[4] Ctr Hosp Regional Georges Rawiri Lambarene, Lambarene, Gabon

[5] Lab Prof Daniel Gahouma, Libreville, Gabon

[6] Univ Sci Sante, Dept Bacteriol Virol, Libreville, Gabon

[7] Ctr Interdisciplinaire Rech Med Franceville, France, Gabon

[8] Ctr Hosp Univ Mere Enfant, Fdn Jeanne EBORI, Libreville, Gabon

[9] German Ctr Infect Res DZIF, Tubingen, Germany

[10] Med Univ Vienna, Vienna, Austria

[11] Vietnamese German Ctr Med Res, VG CARE, Hanoi, Vietnam

[12] Fdn Rech Sci, Cotonou, Benin

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 114卷

关键词：

SARS-CoV-2; B.1.1.318; Variant of concern; B.1.1.7; Transmission; Gabon; Central Africa; Oxford Nanopore; MinION;

D O I：

10.1016/j.ijid.2021.10.057

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy. Methods: Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages. Results: The results highlighted an increase (46%) in the alpha VOC (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G + E484K + Y144del), was detected. Conclusion: With the second wave ongoing, these findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policymakers in selecting an appropriate vaccine for this population. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：151 / 154

页数：4

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