A simple one-pot procedure for the iminium salt formation:: an efficient route to β-aryiethylamines

被引：8

作者：

Ku, YY ^{[1
]}

Grieme, T ^{[1
]}

Pu, YM ^{[1
]}

Bhatia, AV ^{[1
]}

King, SA ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Chem Proc Res & Dev, N Chicago, IL 60064 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

关键词：

beta-Arylethylamines; iminium salt; Mannich reaction;

D O I：

10.1016/j.tetlet.2005.01.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and highly efficient process for the preparation of beta-arylethylamines 7 was developed. Benzylic organozinc compounds 10 were reacted with the iminium salts 9 generated in situ from the amine salt 8 and para formaldehyde in one pot and in a polar and aprotic solvent, such as NMP. A variety of the beta-arylethylamines were prepared in 43-91% yields. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1471 / 1474

页数：4

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