Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels

被引：28

作者：

Wu, Xianjin ^{[1
,2
]}

Zeng, Rong ^{[3
]}

Wu, Shaoke ^{[3
]}

Zhong, Jixin ^{[4
]}

Yang, Lawei ^{[5
]}

Xu, Junfa ^{[6
,7
]}

机构：

[1] Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China

[2] Guangdong Med Coll, Affiliated Hosp, Dept Clin Lab, Zhanjiang 524001, Guangdong, Peoples R China

[3] Guangdong Med Coll, Affiliated Hosp, Orthoped Ctr, Zhanjiang 524001, Guangdong, Peoples R China

[4] Guangdong Med Coll, Affiliated Hosp, Ctr Oncol, Zhanjiang 524001, Guangdong, Peoples R China

[5] Guangdong Med Coll, Clin Res Ctr, Zhanjiang 524001, Guangdong, Peoples R China

[6] Guangdong Med Coll, Inst Lab Med, Dongguan 523808, Peoples R China

[7] Guangdong Prov Key Lab Med Mol Diagnost, Dongguan 523808, Peoples R China

来源：

GENE | 2015年 / 557卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Breast cancer (BC); MicroRNA (miRNA); IsomiR; Expression; CIRCULATING MIRNAS; GENE-EXPRESSION; MICRORNAS; PLASMA; BIOMARKERS; MIR-155; MIR-21; CELLS;

D O I：

10.1016/j.gene.2014.12.030

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Breast cancer (BC) is the main factor that leads cause of cancer death in women worldwide. A class of small non-coding RNAs, microRNAs (miRNAs), has been widely studied in human cancers as crucial regulatory molecule. Recent studies indicate that a series of isomiRs can be yielded from a miRNA locus, and these physiological miRNA isoforms have versatile roles in miRNA biogenesis. Herein, we performed a comprehensive analysis of miRNAs at the miRNA and isomiR levels in BC using next-generation sequencing data from The Cancer Genome Atlas (TCGA). Abnormally expressed miRNA (miR-21, miR-221, miR-155, miR-30e and miR-25) and isomiR profiles could be obtained at the miRNA and isomiR levels, and similar biological roles could be detected. IsomiR expression profiles should be further concerned, and especially isomiRs are actual regulatory molecules in the miRNA mRNA regulatory networks. The study provides a comprehensive expression analysis at the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：195 / 200

页数：6

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