Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

被引：830
|
作者：
Beatty, Gregory L. [1 ]
Gladney, Whitney L. [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Med, Abramson Canc Ctr,Div Hematol Oncol, Philadelphia, PA 19105 USA
来源：
CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 04期
关键词：
EXOME ANALYSIS REVEALS; CLASS-I EXPRESSION; TUMOR-CELLS; MALIGNANT-CELLS; ANTIGEN; IPILIMUMAB; SAFETY; IMMUNOSURVEILLANCE; LYMPHOCYTES; SUPPRESSION;
D O I：
10.1158/1078-0432.CCR-14-1860
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. (C) 2014 AACR.
引用
收藏
页码：687 / 692
页数：6
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