Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

被引：830
|
作者：
Beatty, Gregory L. [1 ]
Gladney, Whitney L. [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Med, Abramson Canc Ctr,Div Hematol Oncol, Philadelphia, PA 19105 USA
来源：
CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 04期
关键词：
EXOME ANALYSIS REVEALS; CLASS-I EXPRESSION; TUMOR-CELLS; MALIGNANT-CELLS; ANTIGEN; IPILIMUMAB; SAFETY; IMMUNOSURVEILLANCE; LYMPHOCYTES; SUPPRESSION;
D O I：
10.1158/1078-0432.CCR-14-1860
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. (C) 2014 AACR.
引用
收藏
页码：687 / 692
页数：6
相关论文
共 50 条
  • [31] The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy
    Leone, Kevin
    Poggiana, Cristina
    Zamarchi, Rita
    DIAGNOSTICS, 2018, 8 (03):
  • [32] Immune escape mechanisms and therapeutic approaches in cancer: the cancer-immunity cycle
    Starzer, Angelika M.
    Preusser, Matthias
    Berghoff, Anna S.
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2022, 14
  • [33] Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy
    Peipp, Matthias
    Dudziak, Diana
    Kellner, Christian
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)
  • [34] Tumour escape from the immune response: the last hurdle for successful immunotherapy of cancer?
    Pawelec, G
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 1999, 48 (07) : 343 - 345
  • [35] Tumour escape from the immune response: the last hurdle for successful immunotherapy of cancer?
    Graham Pawelec
    Cancer Immunology, Immunotherapy, 1999, 48 : 343 - 345
  • [36] HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy
    Anderson, Per
    Aptsiauri, Natalia
    Ruiz-Cabello, Francisco
    Garrido, Federico
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (03) : 556 - 565
  • [37] CD47/SIRPα pathway mediates cancer immune escape and immunotherapy
    Jia, Xiao
    Yan, Bingjun
    Tian, Xiaoqing
    Liu, Qian
    Jin, Jianhua
    Shi, Juanjuan
    Hou, Yongzhong
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 17 (13): : 3281 - 3287
  • [38] HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy
    Per Anderson
    Natalia Aptsiauri
    Francisco Ruiz-Cabello
    Federico Garrido
    Cellular & Molecular Immunology, 2021, 18 : 556 - 565
  • [39] T-cell-directed cancer vaccines: mechanisms of immune escape and immune tolerance
    Phan, GQ
    Wang, E
    Marincola, FM
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2001, 1 (03) : 511 - 523
  • [40] Immune escape and immunotherapy of acute myeloid leukemia
    Vago, Luca
    Gojo, Ivana
    JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (04): : 1552 - 1564
12345