Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

被引：831
作者：
Beatty, Gregory L. [1 ]
Gladney, Whitney L. [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Med, Abramson Canc Ctr,Div Hematol Oncol, Philadelphia, PA 19105 USA
来源：
CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 04期
关键词：
EXOME ANALYSIS REVEALS; CLASS-I EXPRESSION; TUMOR-CELLS; MALIGNANT-CELLS; ANTIGEN; IPILIMUMAB; SAFETY; IMMUNOSURVEILLANCE; LYMPHOCYTES; SUPPRESSION;
D O I：
10.1158/1078-0432.CCR-14-1860
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. (C) 2014 AACR.
引用
收藏
页码：687 / 692
页数：6
相关论文
共 42 条
  • [1] BURNET FM, 1970, PROG EXP TUMOR RES, V13, P1
  • [2] HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance
    Campoli, M.
    Ferrone, S.
    [J]. ONCOGENE, 2008, 27 (45) : 5869 - 5885
  • [3] Classical and nonclassical HLA class I antigen and NK cell-activating ligand changes in malignant cells: Current challenges and future directions
    Chang, CC
    Campoli, M
    Ferrone, S
    [J]. ADVANCES IN CANCER RESEARCH, VOL 93, 2005, 93 : 189 - 234
  • [4] Oncology Meets Immunology: The Cancer-Immunity Cycle
    Chen, Daniel S.
    Mellman, Ira
    [J]. IMMUNITY, 2013, 39 (01) : 1 - 10
  • [5] Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
    Coulie, Pierre G.
    Van den Eynde, Benoit J.
    van der Bruggen, Pierre
    Boon, Thierry
    [J]. NATURE REVIEWS CANCER, 2014, 14 (02) : 135 - 146
  • [6] Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
    Coussens, Lisa M.
    Zitvogel, Laurence
    Palucka, A. Karolina
    [J]. SCIENCE, 2013, 339 (6117) : 286 - 291
  • [7] Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
    DeNardo, David G.
    Brennan, Donal J.
    Rexhepaj, Elton
    Ruffell, Brian
    Shiao, Stephen L.
    Madden, Stephen F.
    Gallagher, William M.
    Wadhwani, Nikhil
    Keil, Scott D.
    Junaid, Sharfaa A.
    Rugo, Hope S.
    Hwang, E. Shelley
    Jirstroem, Karin
    West, Brian L.
    Coussens, Lisa M.
    [J]. CANCER DISCOVERY, 2011, 1 (01) : 54 - 67
  • [8] Dual Roles for Immunity in Gastrointestinal Cancers
    Ferrone, Cristina
    Dranoff, Glenn
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (26) : 4045 - 4051
  • [9] Innate and adaptive immune cells in the tumor microenvironment
    Gajewski, Thomas F.
    Schreiber, Hans
    Fu, Yang-Xin
    [J]. NATURE IMMUNOLOGY, 2013, 14 (10) : 1014 - 1022
  • [10] Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Galon, Jerom
    Costes, Anne
    Sanchez-Cabo, Fatima
    Kirilovsky, Amos
    Mlecnik, Bernhard
    Lagorce-Pages, Christine
    Tosolini, Marie
    Camus, Matthieu
    Berger, Anne
    Wind, Philippe
    Zinzindohoue, Franck
    Bruneval, Patrick
    Cugnenc, Paul-Henri
    Trajanoski, Zlatko
    Fridman, Wolf-Herman
    Pages, Franck
    [J]. SCIENCE, 2006, 313 (5795) : 1960 - 1964
12345