Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

被引：858

作者：

Beatty, Gregory L. ^{[1
]}

Gladney, Whitney L. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Abramson Canc Ctr,Div Hematol Oncol, Philadelphia, PA 19105 USA

来源：

CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 04期

关键词：

EXOME ANALYSIS REVEALS; CLASS-I EXPRESSION; TUMOR-CELLS; MALIGNANT-CELLS; ANTIGEN; IPILIMUMAB; SAFETY; IMMUNOSURVEILLANCE; LYMPHOCYTES; SUPPRESSION;

D O I：

10.1158/1078-0432.CCR-14-1860

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. (C) 2014 AACR.

引用

页码：687 / 692

页数：6

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