Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1

被引：20

作者：

Jiao, Fu-Rong ^{[1
,2
]}

Gu, Bin-Bin ^{[2
]}

Zhu, Hong-Rui ^{[2
]}

Zhang, Yun ^{[3
]}

Liu, Ke-Chun ^{[3
]}

Zhang, Wei ^{[2
]}

Han, Hua ^{[4
]}

Xu, Shi-Hai ^{[1
]}

Lin, Hou-Wen ^{[2
,5
]}

机构：

[1] Jinan Univ, Coll Pharm, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R China

[2] Shanghai Jiao Tong Univ, Ren Ji Hosp, Res Ctr Marine Drugs, State Key Lab Oncogene & Related Genes,Sch Med,De, Shanghai 200127, Peoples R China

[3] Qilu Univ Technol, Inst Biol, Jinan 250103, Peoples R China

[4] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China

[5] Shanghai Univ Med & Hlth Sci, Key Lab Mol Imaging, Shanghai 201318, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 16期

基金：

中国国家自然科学基金;

关键词：

ACID; ZEBRAFISH; SKELETON; STEROIDS;

D O I：

10.1021/acs.joc.0c02049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asperfloketals A (1) and B (2), two 1(10 -> 6)-abeo-14,15-secosteroids featuring a novel trioxahexaheterocyclic ring system, were isolated from the sponge-associated fungus Aspergillus flocculosus 16D-1. Their structures were elucidated by extensive spectroscopic analysis and NMR chemical shifts calculations, supported by DP4+ probability analysis, and their absolute configurations were determined by ECD calculations and the modified Mosher's method. Asperfloketals A and B showed strong anti-inflammatory activity in the CuSO4-induced transgenic fluorescent zebrafish but displayed no cytotoxicity against HeLa, HepG2, and SW480 cell lines.

引用

页码：10954 / 10961

页数：8

共 2 条

[1] Asperflotone, an 8(14→15)-abeo-Ergostane from the Sponge-Derived Fungus Aspergillus flocculosus 16D-1
Gu, Bin-Bin
Wu, Wei
Jiao, Fu-Rong
Jiao, Wei-hua
Li, Lei
Sun, Fan
Wang, Shu-Ping
Yang, Fan
Lin, Hou-Wen
JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (01) : 300 - 306
[2] Aspersecosteroids A and B, Two 11(9 → 10)-abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D-1
Gu, Bin-Bin
Wu, Wei
Jiao, Fu-Rong
Jiao, Wei-hua
Li, Lei
Sun, Fan
Wang, Shu-Ping
Yang, Fan
Lin, Hou-Wen
ORGANIC LETTERS, 2018, 20 (24) : 7957 - 7960

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