Surrogate markers of B cell non-Hodgkin's lymphoma in patients with hepatitis C virus-related cryoglobulinaemia vasculitis

被引:15
作者
Geri, Guillaume [1 ,2 ]
Terrier, Benjamin [1 ,2 ]
Semoun, Oren [3 ]
Saadoun, David [1 ,2 ]
Sene, Damien [1 ,2 ]
Charlotte, Frederic [4 ]
Merle-Beral, Helene [5 ]
Musset, Lucile [6 ]
Resche-Rigon, Matthieu [3 ]
Cacoub, Patrice [1 ,2 ]
机构
[1] Hop La Pitie Salpetriere, AP HP, Serv Med Interne 2, F-75651 Paris 13, France
[2] Univ Paris 06, CNRS, UMR 7211, Paris, France
[3] Hop St Louis, AP HP, Dept Informat Med & Biostat, Paris, France
[4] Hop La Pitie Salpetriere, AP HP, Serv Anat Pathol, F-75651 Paris 13, France
[5] Hop La Pitie Salpetriere, AP HP, Serv Hematol Biol, F-75651 Paris 13, France
[6] Hop La Pitie Salpetriere, AP HP, Serv Immunochim, F-75651 Paris 13, France
关键词
MIXED CRYOGLOBULINEMIA; VILLOUS LYMPHOCYTES; SPLENIC LYMPHOMA; INFECTION;
D O I
10.1136/ard.2010.132001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To evaluate clinical and biological surrogate markers associated with the presence of B cell non-Hodgkin's lymphoma (B-NHL) in patients with hepatitis C virus (HCV) with mixed cryoglobulinaemia (MC) vasculitis. Methods A total of 104 patients with HCV-MC vasculitis (including 20 with B-NHL) were included. The main clinical and biological markers associated with the presence of B-NHL were evaluated. Results Patients with B-NHL compared to those without showed higher rates of poor general status (40% vs 16.7%; p=0.032), purpura (90% vs 66.7%; p=0.05), renal (50% vs 28.6%; p=0.11) and cardiac involvement (15% vs 0%; p=0.0006), higher cryoglobulin levels (1.44 g/litre vs 0.67 g/litre; p=0.0004), and lower C4 (0.025 g/litre vs 0.06 g/litre; p=0.001) and.-globulin levels (5.3 g/litre vs 13.3 g/litre; p<0.0001). The free light chain kappa/lambda ratio was more frequently abnormal in patients with than without B-NHL (64.3% vs 33.3%, p=0.10). On multivariate analysis, only gamma-globulin level was associated with the presence of B-NHL (OR 0.77 (95% CI -0.44 to -0.13), p=0.0006). The optimal cutoff value for gamma-globulin level was 9 g/litre, with sensitivity, specificity, positive and negative predictive values for the presence of B-NHL of 75%, 82%, 50% and 93%, respectively. Conclusions In patients with HCV-MC, a low.-globulin level (<9 g/litre) is strongly associated with the presence of B-NHL.
引用
收藏
页码:2177 / 2180
页数:4
相关论文
共 50 条
[41]   Hepatitis C Virus Related Liver Dysfunction During Chemotherapy for Hodgkin's Lymphoma [J].
Erol, Serpil ;
Kadanali, Ayten ;
Ozkurt, Zulal ;
Kiki, Ihami ;
Parlak, Mehmet .
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 2012, 22 (01) :58-61
[42]   Hepatitis Virus-associated Non-hodgkin Lymphoma: Pathogenesis and Treatment Strategies [J].
Zhang, Wenjing ;
Du, Fan ;
Wang, Li ;
Bai, Tao ;
Zhou, Xiang ;
Mei, Heng .
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2023, 11 (05) :1256-1266
[43]   Co-occurrence of diffuse large B cell non-hodgkin lymphoma and chronic hepatitis C in Algerian patients: Two case reports [J].
Chaabna, Karima ;
Soerjomataram, Isabelle ;
Rouabhia, Samir ;
Chichoune, Salima ;
Scholtes, Caroline ;
Vanhems, Philippe ;
Saidi, Mahdia ;
Forman, David .
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2013, 9 (03) :532-533
[44]   Alcoholism worsens the survival of patients with hepatitis B virus and C virus-related hepatocellular carcinoma [J].
Lee, Yun-Hsuan ;
Hsu, Chia-Yang ;
Hsia, Cheng-Yuan ;
Huang, Yi-Hsiang ;
Su, Chien-Wei ;
Chiou, Yi-You ;
Lin, Han-Chieh ;
Huo, Teh-Ia ;
Lee, Shou-Dong .
HEPATOLOGY INTERNATIONAL, 2013, 7 (02) :645-654
[45]   Hepatitis C virus-related hepatitis flare after immunochemotherapy in a patient with follicular lymphoma [J].
Motomura, Yotaro ;
Yoshifuji, Kota ;
Tanaka, Keisuke ;
Sakashita, Chizuko ;
Umezawa, Yoshihiro ;
Nagao, Toshikage ;
Nitta, Sayuri ;
Asahina, Yasuhiro ;
Mori, Takehiko ;
Yamamoto, Masahide .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2024, 64 (04) :313-317
[46]   Current possibilities for treatment for hepatitis C virus-induced cryoglobulinemic vasculitis and B-cell lymphoma [J].
Ignatova, T. M. ;
Mukhin, N. A. .
TERAPEVTICHESKII ARKHIV, 2012, 84 (11) :81-88
[47]   Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy [J].
Taborelli, Martina ;
Polesel, Jerry ;
Montella, Maurizio ;
Libra, Massimo ;
Tedeschi, Rosamaria ;
Battiston, Monica ;
Spina, Michele ;
Di Raimondo, Francesco ;
Pinto, Antonio ;
Crispo, Anna ;
Grimaldi, Maria ;
Franceschi, Silvia ;
Dal Maso, Luigino ;
Serraino, Diego .
INFECTIOUS AGENTS AND CANCER, 2016, 11
[48]   Hepatitis B virus-related cryogobulinemic vasculitis. The role of antiviral nucleot(s)ide analogues: a review [J].
Mazzaro, C. ;
Dal Maso, L. ;
Visentini, M. ;
Gitto, S. ;
Andreone, P. ;
Toffolutti, F. ;
Gattei, V .
JOURNAL OF INTERNAL MEDICINE, 2019, 286 (03) :290-298
[49]   Specific prognostic factors in hepatitis B virus-related and non-hepatitis B virus-related intrahepatic cholangiocarcinoma after macroscopic curative resection [J].
Huang, Jianbo ;
Wang, Xiangyu ;
Zhu, Ying ;
Wang, Zheng ;
Li, Jianhua ;
Xu, Da ;
Wang, Shenghao ;
Li, Tian-En ;
Lu, Lu .
JOURNAL OF SURGICAL ONCOLOGY, 2019, 119 (01) :40-46
[50]   Antiviral therapy is associated with a better survival in patients with hepatitis C virus and B-cell non-Hodgkin lymphomas, ANRS HC-13 lympho-C study [J].
Michot, Jean-Marie ;
Canioni, Danielle ;
Driss, Henda ;
Alric, Laurent ;
Cacoub, Patrice ;
Suarez, Felipe ;
Sibon, David ;
Thieblemont, Catherine ;
Dupuis, Jehan ;
Terrier, Benjamin ;
Feray, Cyrille ;
Tilly, Herve ;
Pol, Stanislas ;
Leblond, Veronique ;
Settegrana, Catherine ;
Rabiega, Pascaline ;
Barthe, Yoann ;
Hendel-Chavez, Houria ;
Nguyen-Khac, Florence ;
Merle-Beral, Helene ;
Berger, Francoise ;
Molina, Thierry ;
Charlotte, Frederic ;
Carrat, Fabrice ;
Davi, Frederic ;
Hermine, Olivier ;
Besson, Caroline .
AMERICAN JOURNAL OF HEMATOLOGY, 2015, 90 (03) :197-203