Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

被引：118

作者：

Lator, Alexis ^{[1
]}

Gaillard, Sylvain ^{[1
]}

Poater, Albert ^{[2
]}

Renaud, Jean-Luc ^{[1
]}

机构：

[1] Normandie Univ, LCMT, ENSICAEN, UNICAEN,CNRS, 6 Blvd Marechal Juin, F-14000 Caen, France

[2] Univ Girona, Dept Quim, IQCC, C Ma Aurelia Capmany 69, Girona 17003, Catalonia, Spain

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 19期

关键词：

LIGAND-EXCHANGE REACTION; TRICARBONYL COMPLEXES; REDUCTIVE METHYLATION; AROMATIC-AMINES; CARBON-DIOXIDE; FORMIC-ACID; ALKYLATION; EFFICIENT; NITRILES; ALCOHOLS;

D O I：

10.1021/acs.orglett.8b02080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iron(0) complex bearing a cyclopentadienone ligand catalyzed N-methylation and N-ethylation of aryl and aliphatic amines with methanol or ethanol in mild and basic conditions through a hydrogen autotransfer borrowing process is reported. A broad range of aromatic and aliphatic amines underwent mono- or dimethylation in high yields. DFT calculations suggest molecular hydrogen acts not only as a reducing agent but also as an additive to displace thermodynamic equilibria.

引用

页码：5985 / 5990

页数：6

共 27 条

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