One-carbon metabolism for cancer diagnostic and therapeutic approaches

被引：33

作者：

Asai, Ayumu ^{[1
,2
,3
]}

Konno, Masamitsu ^{[2
]}

Koseki, Jun ^{[1
]}

Taniguchi, Masateru ^{[3
]}

Vecchione, Andrea ^{[4
]}

Ishii, Hideshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Med Data Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Frontier Sci Canc & Chemotherapy, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Inst Sci & Ind Res, Artificial Intelligence Res Ctr, 8-1 Mihogaoka, Osaka 5670047, Japan

[4] Univ Rome Sapienza, Santo Andrea Hosp, Dept Clin & Mol Med, Via Grottarossa, I-103500189 Rome, Italy

来源：

CANCER LETTERS | 2020年 / 470卷

关键词：

Folate; Methionine; Methylation; DNA synthesis; Anticancer drugs; DNA METHYLATION PROFILES; SQUAMOUS-CELL CARCINOMA; STEM-CELLS; METHIONINE RESTRICTION; DEOXYRIBONUCLEIC-ACID; PROMOTER METHYLATION; COLORECTAL-CANCER; SOMATIC MUTATIONS; METTL3; PROMOTES; DIETARY-FOLATE;

D O I：

10.1016/j.canlet.2019.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Altered metabolism is critical for the rapid and unregulated proliferation of cancer cells; hence the requirement for an abundant source of nucleotides. One characteristic of this metabolic reprogramming is in one-carbon (1C) metabolism, which is particularly noteworthy for its role in DNA synthesis. Various forms of methylation are also noteworthy as they relate to cancer cell survival and proliferation. In recent years, 1C metabolism has received substantial attention for its role in cancer malignancy via these functions. Therefore, therapeutic inhibitors targeting 1C metabolism have been utilized as anticancer drugs. This review outlines the importance of 1C metabolism and its clinical application in cancer. Understanding 1C metabolism could aid the development of novel cancer diagnostic and therapeutic methods.

引用

页码：141 / 148

页数：8