Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats

被引：45

作者：

Yamasaki, M

Mansho, K

Ogino, Y

Kasai, M

Tachibana, H

Yamada, K

机构：

[1] Kyushu Univ 4609, Grad Sch,Food Chem Lab, Dept Biosci & Biotechnol, Div Bioresource & Bioenvironm Sci,Higashi Ku, Fukuoka 8128581, Japan

[2] Rinol Oil Mills Co Ltd, Nagoya Factory, Minato Ku, Nagoya, Aichi, Japan

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2000年 / 11卷 / 09期

关键词：

conjugated linoleic acid; leptin; white adipose tissue; fatty acid composition;

D O I：

10.1016/S0955-2863(00)00116-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to clarify the effect of conjugated linoleic acid on lipid accumulation in adipose tissue. Sprague-Dawley rats were fed a diet containing 2% conjugated linoleic acid for 1, 3, 6, and 12 weeks. In rats fed 2% conjugated linoleic acid, the weight of perirenal white adipose tissue was comparable with that of rats fed a conjugated linoleic acid-free diet. For fatty acid composition of perirenal white adipose tissue, both 16:1/16:0 and 18:1/18:0 ratios were significantly lower in the conjugated linoleic acid-fed group than the control group. Although there was no remarkable difference in serum triglyceride, total cholesterol, and phospholipid levels between dietary groups, serum leptin level was significantly lower than the control group, and lipid content in the perirenal white adipose tissue exerted a tendency toward low compared to the control value at 1-week feeding. On the other hand, leptin level in perirenal white adipose tissue was significantly lower in the conjugated linoleic acid-fed group than the control group at 12-week feeding. In conclusion, these observations suggest dietary conjugated linoleic acid is an acute reducer of serum leptin level. This may afford an explanation of the mechanism of anti-obesity effect in conjugated linoleic acid. (J. Nutr. Biochem. 11:467-471, 2000) (C) Elsevier Science Inc. 2000. All rights reserved.

引用

页码：467 / 471

页数：5

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