Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

被引：108

作者：

Madrid, PB

Sherrill, J

Liou, AP

Weisman, JL

DeRisi, JL

Guy, RK ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.bmcl.2004.12.037

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1015 / 1018

页数：4

共 50 条

[11] Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains
Kondaparla, Srinivasarao
Soni, Awakash
Manhas, Ashan
Srivastava, Kumkum
Puri, Sunil K.
Katti, S. B.
RSC ADVANCES, 2016, 6 (107): : 105676 - 105689
[12] ADSORPTION SPECTRA AND STRUCTURE OF SUBSTITUTED QUINOLINES, INTERMEDIATES FOR ANTIMALARIAL DRUGS .5. STRUCTURE AND TAUTOMERISM OF 2-AMINOQUINOLINES AND 4-AMINOQUINOLINES
BLIZNYUKOV, VI
SOLONSKAYA, NT
ZHURNAL OBSHCHEI KHIMII, 1958, 28 (05): : 1241 - 1247
[13] A FACILE SYNTHESIS OF 2-ARYL-SUBSTITUTED AND 2-HETEROARYL-SUBSTITUTED 4-AMINOQUINOLINES
STREKOWSKI, L
KONG, SB
CEGLA, MT
HARDEN, DB
HETEROCYCLES, 1989, 29 (03) : 539 - 545
[14] CP-MLR/PLS-directed QSAR studies on the antimalarial activity and cytotoxicity of substituted 4-aminoquinolines
Manish K. Gupta
Medicinal Chemistry Research, 2013, 22 : 3497 - 3509
[15] CP-MLR/PLS-directed QSAR studies on the antimalarial activity and cytotoxicity of substituted 4-aminoquinolines
Gupta, Manish K.
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (07) : 3497 - 3509
[16] DIETHYL ACETONEDICARBOXYLATE - A PRECURSOR FOR THE SYNTHESIS OF NEW SUBSTITUTED 4-AMINOQUINOLINES AND FUSED 4-AMINOPYRIDINES
CHARVAT, T
POTACEK, M
MAREK, J
MONATSHEFTE FUR CHEMIE, 1995, 126 (03): : 333 - 340
[17] Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities
Kaur, Kirandeep
Jain, Meenakshi
Khan, Shabana I.
Jacob, Melissa R.
Tekwani, Babu L.
Singh, Savita
Singh, Prati Pal
Jain, Rahul
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 52 : 230 - 241
[18] Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
Ongarora, Dennis S. B.
Strydom, Natasha
Wicht, Kathryn
Njoroge, Mathew
Wiesner, Lubbe
Egan, Timothy J.
Wittlin, Sergio
Jurva, Ulrik
Masimirembwa, Collen M.
Chibale, Kelly
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (17) : 5419 - 5432
[19] Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines
Grams, Estevao Silveira
Silva Ramos, Alessandro
Neves Muniz, Mauro
Rambo, Raoni S.
Alberton Perello, Marcia
Sperotto, Nathalia
Calle Gonzalez, Laura
Duarte, Lovaine Silva
Galina, Luiza
Silva Dadda, Adilio
Arrache Goncalves, Guilherme
Valim Bizarro, Cristiano
Basso, Luiz Augusto
Machado, Pablo
MOLECULES, 2022, 27 (08):
[20] Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues (vol 12, pg 6465, 2004)
Monga, V
Nayyar, A
Vaitilingam, B
Palde, PB
Jhamb, SS
Kaur, S
Singh, PP
Jain, R
BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (05) : 1879 - 1879

← 1 2 3 4 5 →