Physiology and pathophysiology of the RANKL/RANK system

被引：40
作者：
Hanada, Reiko [1 ]
Hanada, Toshikatsu [1 ]
Penninger, Josef M. [1 ]
机构：
[1] Austrian Acad Sci, Inst Mol Biotechnol IMBA, A-1030 Vienna, Austria
来源：
BIOLOGICAL CHEMISTRY | 2010年 / 391卷 / 12期
基金：
欧洲研究理事会;
关键词：
bone physiology; central nervous systems; fever; immunology; osteoporosis; OSTEOCLAST DIFFERENTIATION FACTOR; BONE-MINERAL DENSITY; FACTOR RECEPTOR FAMILY; POSTMENOPAUSAL WOMEN; OSTEOPROTEGERIN-LIGAND; INHIBITS OSTEOCLASTOGENESIS; CRYSTAL-STRUCTURE; MAMMARY-GLAND; BREAST-CANCER; CELL FUNCTION;
D O I：
10.1515/BC.2010.149
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.
引用
收藏
页码：1365 / 1370
页数：6
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