Physiology and pathophysiology of the RANKL/RANK system

被引：40

作者：

Hanada, Reiko ^{[1
]}

Hanada, Toshikatsu ^{[1
]}

Penninger, Josef M. ^{[1
]}

机构：

[1] Austrian Acad Sci, Inst Mol Biotechnol IMBA, A-1030 Vienna, Austria

来源：

BIOLOGICAL CHEMISTRY | 2010年 / 391卷 / 12期

基金：

欧洲研究理事会;

关键词：

bone physiology; central nervous systems; fever; immunology; osteoporosis; OSTEOCLAST DIFFERENTIATION FACTOR; BONE-MINERAL DENSITY; FACTOR RECEPTOR FAMILY; POSTMENOPAUSAL WOMEN; OSTEOPROTEGERIN-LIGAND; INHIBITS OSTEOCLASTOGENESIS; CRYSTAL-STRUCTURE; MAMMARY-GLAND; BREAST-CANCER; CELL FUNCTION;

D O I：

10.1515/BC.2010.149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

引用

页码：1365 / 1370

页数：6

共 53 条

[1] A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function [J].

Anderson, DM ;

Maraskovsky, E ;

Billingsley, WL ;

Dougall, WC ;

Tometsko, ME ;

Roux, ER ;

Teepe, MC ;

DuBose, RF ;

Cosman, D ;

Galibert, L .

NATURE, 1997, 390 (6656) :175-179

[2] Osteoimmunology - Bone versus immune system [J].

Arron, JR ;

Choi, Y .

NATURE, 2000, 408 (6812) :535-536

[3] Control of mammary stem cell function by steroid hormone signalling [J].

Asselin-Labat, Marie-Liesse ;

Vaillant, Francois ;

Sheridan, Julie M. ;

Pal, Bhupinder ;

Wu, Di ;

Simpson, Evan R. ;

Yasuda, Hisataka ;

Smyth, Gordon K. ;

Martin, T. John ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. .

NATURE, 2010, 465 (7299) :798-802

[4] Fever [J].

Bartfai, Tamas ;

Conti, Bruno .

THESCIENTIFICWORLDJOURNAL, 2010, 10 :490-503

[5] Cytokines, PGE2 and endotoxic fever:: a re-assessment [J].

Blatteis, CM ;

Li, SX ;

Li, ZH ;

Feleder, C ;

Perlik, V .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2005, 76 (1-4) :1-18

[6] Effects of denosumab on bone mineral density and bone turnover in postmenopausal women [J].

Bone, Henry G. ;

Bolognese, Michael A. ;

Yuen, Chui Kin ;

Kendler, David L. ;

Wang, Huei ;

Liu, Yu ;

Martin, Javier San .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (06) :2149-2157

[7]

Brown JP, 2009, J BONE MINER RES, V24, P153, DOI [10.1359/jbmr.080901, 10.1359/JBMR.0809010]

[8] Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis [J].

Cohen, Stanley B. ;

Dore, Robin K. ;

Lane, Nancy E. ;

Ory, Peter A. ;

Peterfy, Charles G. ;

Sharp, John T. ;

van der Heijde, Desiree ;

Zhou, Lifen ;

Tsuji, Wayne ;

Newmark, Richard .

ARTHRITIS AND RHEUMATISM, 2008, 58 (05) :1299-1309

[9] Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis [J].

Cummings, Steven R. ;

San Martin, Javier ;

McClung, Michael R. ;

Siris, Ethel S. ;

Eastell, Richard ;

Reid, Ian R. ;

Delmas, Pierre ;

Zoog, Holly B. ;

Austin, Matt ;

Wang, Andrea ;

Kutilek, Stepan ;

Adami, Silvano ;

Zanchetta, Jose ;

Libanati, Cesar ;

Siddhanti, Suresh ;

Christiansen, Claus .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (08) :756-765

[10]

Dantzer R, 2001, ANN NY ACAD SCI, V933, P222

← 1 2 3 4 5 6 →