Synthesis, characterization, and α-glucosidase, cholinesterases, and tyrosinase inhibitory effects of axial substituted silicon and peripheral tetra-substituted copper (II), manganese (III) phthalocyanines

被引：8
作者：
Ozturmen, Berivan Arin [1 ]
Barut, Burak [2 ]
Biyiklioglu, Zekeriya [1 ]
机构：
[1] Karadeniz Tech Univ, Fac Sci, Dept Chem, Trabzon, Turkey
[2] Karadeniz Tech Univ, Fac Pharm, Dept Biochem, Trabzon, Turkey
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2022年 / 36卷 / 08期
关键词：
cholinesterases; phthalocyanine; synthesis; tyrosinase; alpha-glucosidase; AGGREGATION; DERIVATIVES;
D O I：
10.1002/aoc.6781
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this paper, we have synthesized axially di-(3,3-diphenylpropoxy) substituted silicon (DFP-Si) and peripherally tetra-(3,3-diphenylpropoxy) substituted copper (II), manganese (III) phthalocyanines (DFP-Cu, DFP-Mn). Then, the a-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory effects of DFP-Si, DFP-Cu, and DFP-Mn were examined using spectrophotometric methods. DFP-Mn had the highest inhibitor effect on cholinesterases, tyrosinase, and a-glucosidase in a concentration-dependent manner. DFP-Mn inhibited alpha-glucosidase with IC50 value of 17.80 mu M. Also, DFP-Mn also showed higher alpha-glucosidase inhibitory actions that acarbose used as a positive control. The inhibition percentages in the presence of DFP-Mn were 30.64 +/- 2.24%, 51.96 +/- 1.56%, and 72.96 +/- 4.95%, respectively at 20, 40, and 100 mu M on AChE. In the presence of DFP-Mn at 100 mu M, the inhibition percentages were calculated as 52.18 +/- 2.22% against tyrosinase. These results showed that the compound has potential to treat Diabetes mellitus but further studies are needed to confirm the antidiabetic effect of the compound.
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页数：10
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