Iodine-Catalyzed Construction of Dihydrooxepines via 3-Methyl-5-Pyrazolones C-H Oxidation/Functionalization of Quinolines Cascade

被引：2
作者：
Zhang, Rong [1 ]
Wang, Jun [1 ]
Jin, Weiwei [1 ]
Zhang, Yonghong [1 ]
Wang, Bin [1 ]
Xia, Yu [1 ]
Liu, Chenjiang [1 ]
机构：
[1] Xinjiang Univ, Sch Chem, Minist Educ & Xinjiang Uygur Autonomous Reg, Key Lab Oil & Gas Fine Chem,Urumqi Key Lab Green, Urumqi 830046, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 27期
基金：
中国国家自然科学基金;
关键词：
Dihydrooxepines; Iodine; Quinoline; Three-component tandem reaction; Trioxabicycle; N-OXIDES; FUNCTIONALIZATION; CYCLIZATION; ALKYLATION; ACTIVATION; ANNULATION; AMINATION; ANILINES;
D O I：
10.1002/ejoc.202100541
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient iodine-catalyzed [3+3+1] annulation for the construction of dihydrooxepine scaffolds with quinoline units was developed. This strategy involves a seven-membered dihydrooxepine with a broad substrate scope through a formal three-component tandem reaction. Further derivation of the target product produced a trioxabicycle scaffold, which formed the basic core of natural products and pharmaceutical molecules.
引用
收藏
页码：3807 / 3811
页数：5
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