Anti-Inflammatory Activity of a Novel Acetylene Isolated from the Roots of Angelica tenuissima Nakai

被引：5
|
作者：
Choi, Hyun Gyu [1 ]
Choi, Hyukjae [2 ]
Lee, Jeong-Hyung [3 ]
Min, Byung Sun [4 ]
Kim, Jeong Ah [1 ]
机构：
[1] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu 702701, South Korea
[2] Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyeongbuk, South Korea
[3] Kangwon Natl Univ, Coll Nat Sci, Gangwon Do 200701, South Korea
[4] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea
来源：
HELVETICA CHIMICA ACTA | 2016年 / 99卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Angelica tenuissima; Polyacetylenes; NO; iNOS; COX-2; NITRIC-OXIDE SYNTHASE; KAPPA-B ACTIVATION; CELLS; POLYACETYLENES; SUPPRESSION; INHIBITION;
D O I：
10.1002/hlca.201500507
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three polyacetylenes, one novel and two known, were isolated from the root of Angelica tenuissima. Using H-1- and C-13-NMR, COSY, HMBC, and HMQC, their structures were found to be (3R,8S)-heptadeca-1-en-4,6-diyne-3,8-diol (1), falcarindiol (2), and oplopandiol (3). Absolute configurations of compound 1 were established using Mosher's esterification. In addition, the polyacetylenes (1 - 3) were evaluated for their anti-inflammatory activity. Compounds 1 and 3 showed potent inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in RAW267.7 macrophage cells with IC50 values of 4.31 and 5.06 m, respectively. Compound 1 strongly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in a concentration-dependent manner.
引用
收藏
页码：447 / 451
页数：5
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