Colorectal cancer screening: An updated review of the available options

被引:431
作者
Issa, Iyad A. [1 ]
Noureddine, Malak [1 ]
机构
[1] Rafik Hariri Univ Hosp, Dept Gastroenterol & Hepatol, Specialty Clin Ctr 4B,Maamari St, Beirut 33967, Lebanon
关键词
Colorectal cancer; Colonoscopy; Occult blood; Fecal DNA test; Blood DNA test; Screening; Guidelines; COMPUTED TOMOGRAPHIC COLONOGRAPHY; RANDOMIZED CONTROLLED-TRIAL; FECAL IMMUNOCHEMICAL TEST; OCCULT-BLOOD-TESTS; SOCIETY TASK-FORCE; STOOL DNA TEST; SEPTIN; 9; DNA; CT COLONOGRAPHY; COST-EFFECTIVENESS; ADENOMA DETECTION;
D O I
10.3748/wjg.v23.i28.5086
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However, the availability of these tests is limited to areas with high economic resources. Recently, FDA approved a blood-based test (Epi procolon (R)) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence, leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally, we will propose an algorithm for a simple cost-effective CRC screening program.
引用
收藏
页码:5086 / 5096
页数:11
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