Chemical Synthesis with Inductively Heated Copper Flow Reactors

被引：57

作者：

Ceylan, Sascha ^{[1
,2
]}

Klande, Tobias ^{[3
]}

Vogt, Carla ^{[3
]}

Friese, Carsten ^{[4
]}

Kirschning, Andreas ^{[1
,2
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Leibniz Univ Hannover, Ctr Biomol Drug Res BMWZ, D-30167 Hannover, Germany

[3] Leibniz Univ Hannover, Inst Inorgan & Analyt Chem, D-30167 Hannover, Germany

[4] PIT, D-40219 Dusseldorf, Germany

来源：

SYNLETT | 2010年 / 13期

关键词：

click chemistry; copper; heterogeneous catalysis; microreactors; inductive heating; MAGNETIC NANOPARTICLES; ORGANIC-SYNTHESIS; SUZUKI-MIYAURA; CATALYSTS; COMPOSITES; CHEMISTRY; PHASE; IMMOBILIZATION; AZIDES; BATCH;

D O I：

10.1055/s-0030-1258487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1,3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1,2,3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular C-O coupling of 2'-bromobiphenyl-2-carboxylic acid.

引用

页码：2009 / 2013

页数：5

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