Chemical Synthesis with Inductively Heated Copper Flow Reactors

被引：56
作者：
Ceylan, Sascha [1 ,2 ]
Klande, Tobias [3 ]
Vogt, Carla [3 ]
Friese, Carsten [4 ]
Kirschning, Andreas [1 ,2 ]
机构：
[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
[2] Leibniz Univ Hannover, Ctr Biomol Drug Res BMWZ, D-30167 Hannover, Germany
[3] Leibniz Univ Hannover, Inst Inorgan & Analyt Chem, D-30167 Hannover, Germany
[4] PIT, D-40219 Dusseldorf, Germany
来源：
SYNLETT | 2010年 / 13期
关键词：
click chemistry; copper; heterogeneous catalysis; microreactors; inductive heating; MAGNETIC NANOPARTICLES; ORGANIC-SYNTHESIS; SUZUKI-MIYAURA; CATALYSTS; COMPOSITES; CHEMISTRY; PHASE; IMMOBILIZATION; AZIDES; BATCH;
D O I：
10.1055/s-0030-1258487
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1,3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1,2,3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular C-O coupling of 2'-bromobiphenyl-2-carboxylic acid.
引用
收藏
页码：2009 / 2013
页数：5
相关论文
共 62 条
  • [1] Advanced organic synthesis using microreactor technology
    Ahmed-Omer, Batoul
    Brandt, Johan C.
    Wirth, Thomas
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (05) : 733 - 740
  • [2] Baxendale IR, 2007, ERNST SCHERING FOUND, V3, P151
  • [3] BAXENDALE IR, 2008, MICROREACTORS ORGANI, P84
  • [4] Application of microwave irradiation to phase-transfer catalyzed reactions
    Bogdal, Dariusz
    Loupy, Andre
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2008, 12 (04) : 710 - 722
  • [5] The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles
    Bogdan, Andrew R.
    Sach, Neal W.
    [J]. ADVANCED SYNTHESIS & CATALYSIS, 2009, 351 (06) : 849 - 854
  • [6] Ceylan S., 2009, Recoverable and Recyclable Catalysts, P379, DOI [10.1002/9780470682005.ch13, DOI 10.1002/9780470682005.CH13]
  • [7] Inductive Heating for Organic Synthesis by Using Functionalized Magnetic Nanoparticles Inside Microreactors
    Ceylan, Sascha
    Friese, Carsten
    Lammel, Christian
    Mazac, Karel
    Kirschning, Andreas
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (46) : 8950 - 8953
  • [8] Enzyme-purification and catalytic transformations in a microstructured PASSflow reactor using a new tyrosine-based Ni-NTA linker system attached to a polyvinylpyrrolidinone-based matrix
    Draeger, Gerald
    Kiss, Csilla
    Kunz, Ulrich
    Kirschning, Andreas
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (22) : 3657 - 3664
  • [9] Ionic liquid (molten salt) phase organometallic catalysis
    Dupont, J
    de Souza, RF
    Suarez, PAZ
    [J]. CHEMICAL REVIEWS, 2002, 102 (10) : 3667 - 3691
  • [10] Adventures in inner space: Microflow systems for practical organic synthesis
    Fukuyama, Takahide
    Rahman, Taifur
    Sato, Masaaki
    Ryu, Ilhyong
    [J]. SYNLETT, 2008, (02) : 151 - 163
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