Selective C-4 Alkylation of Pyridine by Nickel/Lewis Acid Catalysis

被引：348

作者：

Nakao, Yoshiaki ^{[1
]}

Yamada, Yuuya ^{[1
]}

Kashihara, Natsuko ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 39期

关键词：

H BOND ACTIVATION; AROMATIC HETEROCYCLES; ALKENYLATION; DERIVATIVES; ARYLATION; QUINOLINES; COMPLEXES; REAGENTS; CARBON;

D O I：

10.1021/ja106514b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. A variety of substituents on both alkenes and pyridine are tolerated to give linear 4-alkylpyridines in modest to good yields. The addition across styrene, on the other hand, gives branched 4-alkylpyridines. A single example of C-4-selective alkenylation is also described.

引用

页码：13666 / 13668

页数：3

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