Diabetes Monotherapies versus Metformin-Based Combination Therapy for the Treatment of Type 2 Diabetes

被引:18
作者
Singh, Awadhesh K. [1 ]
Singh, Ritu [1 ]
Chakraborty, Partha Pratim [2 ]
机构
[1] GD Hosp & Diabet Inst, Dept Diabet & Endocrinol, Kolkata, India
[2] Med Coll, Dept Endocrinol & Metab, Kolkata, India
关键词
type; 2; diabetes; monotherapy; combination therapies; efficacy; safety outcomes; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; ADD-ON; MELLITUS; EFFICACY; SAFETY;
D O I
10.2147/IJGM.S295459
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Step-wise addition of antihyperglycemic agents (AHA) after the initiation of metformin monotherapy has been the traditional approach for the treatment of type 2 diabetes mellitus (T2DM) world-wide. Emerging evidence increasingly suggests that metformin-based combination therapy, especially with the newer AHA that lowers HbA1c glucose-dependently and do not potentiate hypoglycemia, could be a potentially better option for durable glycemic control with good tolerability compared to diabetes monotherapy. In this review, we descriptively analyzed the evidence available from the systematic reviews and meta-analyses of randomized head-to-head trials that reported the efficacy and safety outcomes of diabetes monotherapy, metformin-based combination therapies, and monotherapy versus metformin-based combination therapies.
引用
收藏
页码:3833 / 3848
页数:16
相关论文
共 50 条
[41]   Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes [J].
Romanelli, Robert J. ;
Chung, Sukyung ;
Pu, Jia ;
Nimbal, Vani ;
Zhao, Beinan ;
Palaniappan, Latha .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2015, 108 (01) :170-178
[42]   Ertugliflozin for the treatment of type 2 diabetes [J].
Sharma, R. ;
Razdan, K. ;
Kuhad, A. ;
Kuhad, A. .
DRUGS OF TODAY, 2019, 55 (03) :167-175
[43]   Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus [J].
Pandya, Bhavik J. ;
Bron, Morgan ;
McCall, Therese ;
Yu, Andrew P. ;
Chen, Kristina S. ;
Mattson, Miles E. ;
Wu, Eric Q. .
CURRENT MEDICAL RESEARCH AND OPINION, 2011, 27 (01) :189-195
[44]   Canagliflozin: Efficacy and Safety in Combination with Metformin Alone or with Other Antihyperglycemic Agents in Type 2 Diabetes [J].
Qiu, Rong ;
Balis, Dainius ;
Capuano, George ;
Xie, John ;
Meininger, Gary .
DIABETES THERAPY, 2016, 7 (04) :659-678
[45]   Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview [J].
Jaime A. Davidson ;
Lance Sloan .
Advances in Therapy, 2017, 34 :41-59
[46]   Fixed-dose combination of ertugliflozin and metformin hydrochloride for the treatment of type 2 diabetes [J].
Frias, Juan Pablo .
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2019, 14 (02) :75-83
[47]   Effectiveness and Safety of Metformin, Teneligliptin, and Glimepiride Combination Therapy in Type 2 Diabetes: A Quasi Experimental Clinical Trial [J].
Manchi, Rajesh Kumar ;
Chenchula, Santenna ;
Haritha, Manchi .
CURRENT DIABETES REVIEWS, 2025, 21 (06)
[48]   A randomized controlled clinical trial of vildagliptin plus metformin combination therapy in patients with type II diabetes mellitus [J].
Su, Yong ;
Su, Ya-Li ;
Lv, Li-Fang ;
Wang, Li-Min ;
Li, Quan-Zhong ;
Zhao, Zhi-Gang .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2014, 7 (04) :799-803
[49]   Initial Combination Therapy in Type 2 Diabetes [J].
Kim, Ji Yoon ;
Kim, Nam Hoon .
ENDOCRINOLOGY AND METABOLISM, 2024, 39 (01) :23-32
[50]   An alternative combination therapy for type 2 diabetes? [J].
Ostoft, Signe H. ;
Christensen, Mikkel .
LANCET, 2015, 385 (9982) :2020-2022