Diabetes Monotherapies versus Metformin-Based Combination Therapy for the Treatment of Type 2 Diabetes

被引：18

作者：

Singh, Awadhesh K. ^{[1
]}

Singh, Ritu ^{[1
]}

Chakraborty, Partha Pratim ^{[2
]}

机构：

[1] GD Hosp & Diabet Inst, Dept Diabet & Endocrinol, Kolkata, India

[2] Med Coll, Dept Endocrinol & Metab, Kolkata, India

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2021年 / 14卷

关键词：

type; 2; diabetes; monotherapy; combination therapies; efficacy; safety outcomes; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; ADD-ON; MELLITUS; EFFICACY; SAFETY;

D O I：

10.2147/IJGM.S295459

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Step-wise addition of antihyperglycemic agents (AHA) after the initiation of metformin monotherapy has been the traditional approach for the treatment of type 2 diabetes mellitus (T2DM) world-wide. Emerging evidence increasingly suggests that metformin-based combination therapy, especially with the newer AHA that lowers HbA1c glucose-dependently and do not potentiate hypoglycemia, could be a potentially better option for durable glycemic control with good tolerability compared to diabetes monotherapy. In this review, we descriptively analyzed the evidence available from the systematic reviews and meta-analyses of randomized head-to-head trials that reported the efficacy and safety outcomes of diabetes monotherapy, metformin-based combination therapies, and monotherapy versus metformin-based combination therapies.

引用

页码：3833 / 3848

页数：16

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